{
  "meta": {
    "data_length": 1,
    "message": "Biomarker id bmkr:125 retrieved successfully",
    "request_url": "http://api.moalmanac.org/biomarkers?biomarker_id=bmkr%3A125",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001574,
    "timestamp_received": "2026-09-25T00:13:46.244798+00:00Z",
    "timestamp_returned": "2026-09-25T00:13:46.246372+00:00Z",
    "trace_id": "a4810e25-48b4-4cef-9dd5-3a8dbac23635"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "bmkr:125",
      "type": "CategoricalVariant",
      "name": "CDK12 oncogenic variants",
      "constraints": [
        {
          "type": "DefiningLocationConstraint",
          "location": {
            "id": "ga4gh:SL.v6dDopUoppRYaxKGZdqVJHBVgbRVIWIo",
            "type": "SequenceLocation",
            "name": null,
            "aliases": [],
            "description": "Sequence spanning the length of refseq:NP_057591.2, the protein product of the MANE Select coding transcript for CDK12 (refseq:NM_016507.4).",
            "digest": "v6dDopUoppRYaxKGZdqVJHBVgbRVIWIo",
            "sequenceReference": {
              "id": "ga4gh:SQ.PAx2759Yy_waBKMXobh8lS9Z9Mbnr7l9",
              "type": "SequenceReference",
              "name": "NP_057591.2",
              "aliases": [
                "ensembl:ENSP00000398880.3",
                "ga4gh:SQ.PAx2759Yy_waBKMXobh8lS9Z9Mbnr7l9",
                "refseq:NP_057591.2"
              ],
              "description": "The protein product of the MANE Select coding transcript for CDK12 (refseq:NM_016507.4), corresponding to the Refseq protein accession NP_057591.2.",
              "moleculeType": "protein",
              "refgetAccession": "SQ.PAx2759Yy_waBKMXobh8lS9Z9Mbnr7l9",
              "residueAlphabet": "aa"
            },
            "start": 0,
            "end": 1490,
            "sequence": null
          },
          "relations": [],
          "matchCharacteristic": {
            "primaryCoding": {
              "code": "is_within",
              "system": "ga4gh-gks-term:location-match"
            }
          }
        },
        {
          "type": "FeatureContextConstraint",
          "featureContext": {
            "id": "gene:hgnc:24224",
            "conceptType": "Gene",
            "name": "CDK12",
            "primaryCoding": {
              "id": "coding:hgnc:24224",
              "code": "HGNC:24224",
              "system": "https://genenames.org",
              "iris": [
                "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24224"
              ]
            },
            "mappings": [
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:ensembl:ensg00000167258",
                  "code": "ENSG00000167258",
                  "system": "https://www.ensembl.org",
                  "iris": [
                    "https://www.ensembl.org/id/ENSG00000167258"
                  ]
                }
              },
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:ncbi:51755",
                  "code": "51755",
                  "system": "https://www.ncbi.nlm.nih.gov/gene",
                  "iris": [
                    "https://www.ncbi.nlm.nih.gov/gene/51755"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:refseq:NM_016507.4",
                  "code": "NM_016507.4",
                  "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                  "iris": [
                    "https://www.ncbi.nlm.nih.gov/nuccore/NM_016507.4"
                  ]
                }
              }
            ]
          }
        }
      ],
      "extensions": [
        {
          "name": "biomarker_type",
          "value": "Somatic variant"
        },
        {
          "name": "chromosome",
          "value": "17"
        },
        {
          "name": "start_position",
          "value": null
        },
        {
          "name": "end_position",
          "value": null
        },
        {
          "name": "reference_allele",
          "value": null
        },
        {
          "name": "alternate_allele",
          "value": null
        },
        {
          "name": "cdna_change",
          "value": null
        },
        {
          "name": "protein_change",
          "value": null
        },
        {
          "name": "variant_annotation",
          "value": null
        },
        {
          "name": "exon",
          "value": null
        },
        {
          "name": "rsid",
          "value": null
        },
        {
          "name": "hgvsg",
          "value": null
        },
        {
          "name": "hgvsc",
          "value": null
        },
        {
          "name": "requires_oncogenic",
          "value": true
        }
      ]
    }
  ]
}