{
  "meta": {
    "data_length": 1,
    "message": "Biomarker id bmkr:66 retrieved successfully",
    "request_url": "http://api.moalmanac.org/biomarkers?biomarker_id=bmkr%3A66",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.00161,
    "timestamp_received": "2026-09-25T00:13:28.918795+00:00Z",
    "timestamp_returned": "2026-09-25T00:13:28.920405+00:00Z",
    "trace_id": "d404c047-4d50-4227-a937-9fb7f0629bae"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "bmkr:66",
      "type": "CategoricalVariant",
      "name": "FLT3-ITD",
      "constraints": [
        {
          "type": "DefiningLocationConstraint",
          "location": {
            "id": "ga4gh:SL.53HN2VFdgurjdPcQYBRwyfNMHcwRzdID",
            "type": "SequenceLocation",
            "name": "FLT3 ITD Region (Exons 14-15), protein",
            "aliases": [],
            "description": "Sequence within refseq:NP_004110.2, the protein product of the MANE Select coding transcript for FLT3 (refseq:NM_004119.3), corresponding to the juxtamembrane domain and N-terminal portion of tyrosine kinase subdomain 1 (Exons 14-15).",
            "digest": "53HN2VFdgurjdPcQYBRwyfNMHcwRzdID",
            "sequenceReference": {
              "id": "ga4gh:SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH",
              "type": "SequenceReference",
              "name": "NP_004110.2",
              "aliases": [
                "ensembl:ENSP00000241453.7",
                "ga4gh:SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH",
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              ],
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              "moleculeType": "protein",
              "refgetAccession": "SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH",
              "residueAlphabet": "aa"
            },
            "start": 568,
            "end": 648,
            "sequence": null
          },
          "relations": [],
          "matchCharacteristic": {
            "primaryCoding": {
              "code": "is_within",
              "system": "ga4gh-gks-term:location-match"
            }
          }
        },
        {
          "type": "FeatureContextConstraint",
          "featureContext": {
            "id": "gene:hgnc:3765",
            "conceptType": "Gene",
            "name": "FLT3",
            "primaryCoding": {
              "id": "coding:hgnc:3765",
              "code": "HGNC:3765",
              "system": "https://genenames.org",
              "iris": [
                "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3765"
              ]
            },
            "mappings": [
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:ensembl:ensg00000122025",
                  "code": "ENSG00000122025",
                  "system": "https://www.ensembl.org",
                  "iris": [
                    "https://www.ensembl.org/id/ENSG00000122025"
                  ]
                }
              },
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:ncbi:2322",
                  "code": "2322",
                  "system": "https://www.ncbi.nlm.nih.gov/gene",
                  "iris": [
                    "https://www.ncbi.nlm.nih.gov/gene/2322"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:refseq:NM_004119.3",
                  "code": "NM_004119.3",
                  "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                  "iris": [
                    "https://www.ncbi.nlm.nih.gov/nuccore/NM_004119.3"
                  ]
                }
              }
            ]
          }
        }
      ],
      "extensions": [
        {
          "name": "biomarker_type",
          "value": "Somatic variant"
        },
        {
          "name": "chromosome",
          "value": "13"
        },
        {
          "name": "start_position",
          "value": null
        },
        {
          "name": "end_position",
          "value": null
        },
        {
          "name": "reference_allele",
          "value": null
        },
        {
          "name": "alternate_allele",
          "value": null
        },
        {
          "name": "cdna_change",
          "value": null
        },
        {
          "name": "protein_change",
          "value": null
        },
        {
          "name": "variant_annotation",
          "value": "Internal Tandem Duplication (ITD)"
        },
        {
          "name": "exon",
          "value": null
        },
        {
          "name": "rsid",
          "value": null
        },
        {
          "name": "hgvsg",
          "value": null
        },
        {
          "name": "hgvsc",
          "value": null
        },
        {
          "name": "requires_oncogenic",
          "value": true
        }
      ]
    }
  ]
}