{
  "meta": {
    "data_length": 1,
    "message": "Biomarker id bmkr:67 retrieved successfully",
    "request_url": "http://api.moalmanac.org/biomarkers?biomarker_id=bmkr%3A67",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001578,
    "timestamp_received": "2026-09-25T00:13:22.503653+00:00Z",
    "timestamp_returned": "2026-09-25T00:13:22.505231+00:00Z",
    "trace_id": "b900d829-e5f7-4173-bb42-a6dd17edbc71"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "bmkr:67",
      "type": "CategoricalVariant",
      "name": "MET Exon 14 (Splice Site)",
      "constraints": [
        {
          "type": "DefiningLocationConstraint",
          "location": {
            "id": "ga4gh:SL.dNLhs0UIN4aBJCxfRymlkjqL5S-ZRTKK",
            "type": "SequenceLocation",
            "name": null,
            "aliases": [],
            "description": "Sequence within refseq:NP_000236.2, the protein product of the MANE Select coding transcript for MET (refseq:NM_000245.4), corresponding to Exon 14. This exon's protein location shares a codon boundary with the adjacent exons on both sides.",
            "digest": "dNLhs0UIN4aBJCxfRymlkjqL5S-ZRTKK",
            "sequenceReference": {
              "id": "ga4gh:SQ.QITcgkaDXSK1bJllcGyJVlXeD_SiQdfo",
              "type": "SequenceReference",
              "name": "NP_000236.2",
              "aliases": [
                "ensembl:ENSP00000380860.3",
                "ga4gh:SQ.QITcgkaDXSK1bJllcGyJVlXeD_SiQdfo",
                "refseq:NP_000236.2"
              ],
              "description": "The protein product of the MANE Select coding transcript for MET (refseq:NM_000245.4), corresponding to the Refseq protein accession NP_000236.2.",
              "moleculeType": "protein",
              "refgetAccession": "SQ.QITcgkaDXSK1bJllcGyJVlXeD_SiQdfo",
              "residueAlphabet": "aa"
            },
            "start": 962,
            "end": 1010,
            "sequence": null
          },
          "relations": [],
          "matchCharacteristic": {
            "primaryCoding": {
              "code": "is_within",
              "system": "ga4gh-gks-term:location-match"
            }
          }
        },
        {
          "type": "FeatureContextConstraint",
          "featureContext": {
            "id": "gene:hgnc:7029",
            "conceptType": "Gene",
            "name": "MET",
            "primaryCoding": {
              "id": "coding:hgnc:7029",
              "code": "HGNC:7029",
              "system": "https://genenames.org",
              "iris": [
                "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7029"
              ]
            },
            "mappings": [
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:ensembl:ensg00000105976",
                  "code": "ENSG00000105976",
                  "system": "https://www.ensembl.org",
                  "iris": [
                    "https://www.ensembl.org/id/ENSG00000105976"
                  ]
                }
              },
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:ncbi:4233",
                  "code": "4233",
                  "system": "https://www.ncbi.nlm.nih.gov/gene",
                  "iris": [
                    "https://www.ncbi.nlm.nih.gov/gene/4233"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:refseq:NM_000245.4",
                  "code": "NM_000245.4",
                  "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                  "iris": [
                    "https://www.ncbi.nlm.nih.gov/nuccore/NM_000245.4"
                  ]
                }
              }
            ]
          }
        }
      ],
      "extensions": [
        {
          "name": "biomarker_type",
          "value": "Somatic variant"
        },
        {
          "name": "chromosome",
          "value": "7"
        },
        {
          "name": "start_position",
          "value": null
        },
        {
          "name": "end_position",
          "value": null
        },
        {
          "name": "reference_allele",
          "value": null
        },
        {
          "name": "alternate_allele",
          "value": null
        },
        {
          "name": "cdna_change",
          "value": null
        },
        {
          "name": "protein_change",
          "value": null
        },
        {
          "name": "variant_annotation",
          "value": "Splice Site"
        },
        {
          "name": "exon",
          "value": 14
        },
        {
          "name": "rsid",
          "value": null
        },
        {
          "name": "hgvsg",
          "value": null
        },
        {
          "name": "hgvsc",
          "value": null
        },
        {
          "name": "requires_oncogenic",
          "value": true
        }
      ]
    }
  ]
}