{
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    "timestamp_received": "2026-11-09T16:14:22.109048Z",
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    "name": "Molecular Oncology Almanac",
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  "data": [
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      "id": "ind:ema:herceptin:4",
      "type": "Indication",
      "description": "Herceptin is indicated for the treatment of adult patients with HER2 positive early breast cancer (EBC) following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable).",
      "contributions": [
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          "id": "ctrb:vanallenlab:2024-10-20:0",
          "type": "Contribution",
          "description": "Adding EMA approvals for use to database",
          "date": "2024-10-20",
          "contributor": {
            "id": "agent:user:vanallenlab",
            "type": "Agent",
            "agentType": "contributor",
            "name": "Van Allen lab",
            "description": "Van Allen lab, Dana-Farber Cancer Institute"
          }
        },
        {
          "id": "ctrb:ema:2000-08-28:0",
          "type": "Contribution",
          "description": "Indication received approval from the European Commission.",
          "date": "2000-08-28",
          "contributor": {
            "id": "agent:org:ema",
            "type": "Agent",
            "agentType": "organization",
            "name": "European Medicines Agency",
            "description": "Regulatory agency that approves medicines for use in the European Union."
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        {
          "id": "doc:ema:herceptin",
          "type": "Document",
          "documentType": "Regulatory approval",
          "name": "Herceptin (trastuzumab) [product information]. EMA.",
          "title": null,
          "aliases": [],
          "description": "Roche Registration GmbH. Herceptin (trastuzumab) [product information]. European Medicines Agency website. https://www.ema.europa.eu/en/documents/product-information/herceptin-epar-product-information_en.pdf. Revised March 2023. Accessed March 12, 2024.",
          "urls": [
            "https://www.ema.europa.eu/en/documents/product-information/herceptin-epar-product-information_en.pdf",
            "https://www.ema.europa.eu/en/medicines/human/EPAR/herceptin"
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          "doi": null,
          "pmid": null,
          "extensions": [
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                "id": "agent:org:ema",
                "type": "Agent",
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                "name": "European Medicines Agency",
                "description": "Regulatory agency that approves medicines for use in the European Union."
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              "value": "Roche Registration GmbH.",
              "description": "The company that manufactures the cancer drug. Only applicable to market authorization documents."
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              "value": "Herceptin",
              "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
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              "value": "trastuzumab",
              "description": "The generic name of the cancer drug, per this document. Only applicable to market authorization documents."
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              "value": "2010-03-01",
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              "description": "The publication date for the document."
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              "value": null,
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          "value": "The European Medicines Agency (EMA) has authorized trastuzumab for the treatment of adult patients with HER2 positive early breast cancer (EBC) following surgery, chemotherapy (neoadjuvant or adjuvant), and radiotherapy (if applicable). The production information for trastuzumab notes that trastuzumab should only be used in patients with metastatic or early breast cancer whose tumors have either HER2 overexpression or HER2 gene amplification as determined by an accurate and validated assay.",
          "description": "The description text for all Statements derived from this Indication."
        }
      ]
    }
  ]
}