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      "id": "ind:ema:vectibix:2",
      "type": "Indication",
      "description": "Vectibix is indicated for the treatment of adult patients with wild-type RAS metastatic colorectal cancer (mCRC) as monotherapy after failure of fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens.",
      "contributions": [
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          "id": "ctrb:vanallenlab:2024-10-20:0",
          "type": "Contribution",
          "description": "Adding EMA approvals for use to database",
          "date": "2024-10-20",
          "contributor": {
            "id": "agent:user:vanallenlab",
            "type": "Agent",
            "agentType": "contributor",
            "name": "Van Allen lab",
            "description": "Van Allen lab, Dana-Farber Cancer Institute"
          }
        },
        {
          "id": "ctrb:ema:2013-07-25:0",
          "type": "Contribution",
          "description": "Indication received approval from the European Commission.",
          "date": "2013-07-25",
          "contributor": {
            "id": "agent:org:ema",
            "type": "Agent",
            "agentType": "organization",
            "name": "European Medicines Agency",
            "description": "Regulatory agency that approves medicines for use in the European Union."
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      "reportedIn": [
        {
          "id": "doc:ema:vectibix",
          "type": "Document",
          "documentType": "Regulatory approval",
          "name": "Vectibix (panitumumab) [product information]. EMA.",
          "title": null,
          "aliases": [],
          "description": "Amgen Europe B.V. Vectibix (panitumumab) [product information]. European Medicines Agency website. https://www.ema.europa.eu/en/documents/product-information/vectibix-epar-product-information_en.pdf. Revised July 2022. Accessed March 28, 2024.",
          "urls": [
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            "https://www.ema.europa.eu/en/medicines/human/EPAR/vectibix"
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          "pmid": null,
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                "name": "European Medicines Agency",
                "description": "Regulatory agency that approves medicines for use in the European Union."
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              "description": "The organization that published this document."
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              "value": "Amgen Europe B.V.",
              "description": "The company that manufactures the cancer drug. Only applicable to market authorization documents."
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              "value": "Vectibix",
              "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
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              "name": "drug_name_generic",
              "value": "panitumumab",
              "description": "The generic name of the cancer drug, per this document. Only applicable to market authorization documents."
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              "value": "2009-06-18",
              "description": "The publication date for the initial version of this document."
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          "value": "The European Medicines Agency (EMA) has authorized panitumumab as a monotherapy for the treatment of adult patients with wild-type RAS metastatic colorectal cancer (mCRPC) after failure of fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Panitumumab's product information further states that evidence of wild-type RAS (KRAS and NRAS) status is required before initiating treatment with panitumumab and that mutational status should be deteremined by an experienced laboratory using validated test methods for detection of KRAS (exons 2, 3, and 4) and NRAS (exons 2, 3, and 4) variants.",
          "description": "The description text for all Statements derived from this Indication."
        }
      ]
    }
  ]
}