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    "name": "Molecular Oncology Almanac",
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    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-04-09"
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  "data": [
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      "id": "ind:ema.keytruda:12",
      "indication": "KEYTRUDA, in combination with chemotherapy with or without bevacizumab, is indicated for the treatment of persistent, recurrent, or metastatic cervical cancer in adults whose tumours express PD-L1 with a CPS >= 1.",
      "initial_approval_date": "2022-05-17",
      "initial_approval_url": "https://www.ema.europa.eu/en/documents/variation-report/keytruda-h-c-003820-ii-0117-epar-assessment-report-variation_en.pdf",
      "description": "The European Medicines Agency (EMA) has authorized pembrolizumab in combination with chemotherapy and with or without bevacizumab for the treatment of adult patients with persistent, recurrent, or metastatic cervical cancer whose tumors express PD-L1 with a combined positive score (CPS) >= 1. This indication is based on KEYNOTE-826, a multicenter, randomized, double-blind, and placebo-controlled study that studied the efficacy of pembrolizumab in combination with paclitaxel and cisplatin or paclitaxel and carboplatin, with or without bevacizumab in 617 patients meeting this indication's clinical criteria.",
      "raw_biomarkers": null,
      "raw_cancer_type": "Cervical cancer",
      "raw_therapeutics": "Keytruda (pembrolizumab) in combination with chemotherapy with or without bevacizumab",
      "icd10": null,
      "regimen_code": null,
      "reimbursement_category": null,
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      "date_accelerated_approval": null,
      "document": {
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        "type": "Document",
        "documentType": "Regulatory approval",
        "name": "Keytruda (pembrolizumab) [product information]. EMA.",
        "title": null,
        "aliases": [],
        "description": "Merck Sharp & Dohme B.V. Keytruda (pembrolizumab) [product information]. European Medicines Agency website. https://www.ema.europa.eu/en/documents/product-information/keytruda-epar-product-information_en.pdf. Revised January 2024. Accessed March 10, 2024.",
        "urls": [
          "https://www.ema.europa.eu/en/medicines/human/EPAR/keytruda",
          "https://www.ema.europa.eu/en/documents/product-information/keytruda-epar-product-information_en.pdf"
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        "pmid": null,
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              "id": "ema",
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              "agentType": "organization",
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              "description": "Regulatory agency that approves medicines for use in the European Union.",
              "extensions": [
                {
                  "name": "last_updated",
                  "value": "2025-10-01",
                  "description": ""
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                {
                  "name": "url",
                  "value": "https://www.ema.europa.eu/en/medicines",
                  "description": ""
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          {
            "name": "company",
            "value": "Merck Sharp & Dohme B.V.",
            "description": "The company that manufactures the cancer drug. Only applicable to market authorization documents."
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            "name": "drug_name_brand",
            "value": "Keytruda",
            "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
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            "description": "The generic name of the cancer drug, per this document. Only applicable to market authorization documents."
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            "value": "2015-07-30",
            "description": "The publication date for the initial version of this document."
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            "value": null,
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            "value": "2024-01-11",
            "description": "The publication date for the document."
          },
          {
            "name": "status",
            "value": "Active",
            "description": "Whether this document is Active or Deprecated within moalmanac-db."
          }
        ]
      }
    }
  ]
}