{
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    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
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    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-04-09"
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  "data": [
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      "id": "ind:ema.keytruda:13",
      "indication": "KEYTRUDA, in combination with trastuzumab, fluoropyrimidine and platinum-containing chemotherapy, is indicated for the first-line treatment of locally advanced unresectable or metastatic HER2-positive gastric or gastro -oesophageal junction adenocarcinoma in adults whose tumours express PD-L1 with a CPS >= 1.",
      "initial_approval_date": "2023-09-06",
      "initial_approval_url": "https://www.ema.europa.eu/en/documents/variation-report/keytruda-h-c-003820-ii-0133-epar-assessment-report-variation_en.pdf",
      "description": "The European Medicines Agency (EMA) has authorized pembrolizumab in combination with trastuzumab, fluoropyrimidine and platinum-containing chemotherapy for the first-line treatment of adult patients with locally advanced unresectable or metastatic HER2-positive gastric or gastro-esophageal junction adenocarcinoma whose tumors express PD-L1 with a combined positive score (CPS) >= 1.",
      "raw_biomarkers": null,
      "raw_cancer_type": "Gastric or gastro-esophagael junction (GEJ) adenocracinoma",
      "raw_therapeutics": "Keytruda (pembrolizumab) in combination with trastuzumab, fluoropyrimidine, and platinum-containing chemotherapy",
      "icd10": null,
      "regimen_code": null,
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      "date_accelerated_approval": null,
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        "type": "Document",
        "documentType": "Regulatory approval",
        "name": "Keytruda (pembrolizumab) [product information]. EMA.",
        "title": null,
        "aliases": [],
        "description": "Merck Sharp & Dohme B.V. Keytruda (pembrolizumab) [product information]. European Medicines Agency website. https://www.ema.europa.eu/en/documents/product-information/keytruda-epar-product-information_en.pdf. Revised January 2024. Accessed March 10, 2024.",
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        "pmid": null,
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            "value": "Merck Sharp & Dohme B.V.",
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            "value": "Keytruda",
            "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
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            "description": "The generic name of the cancer drug, per this document. Only applicable to market authorization documents."
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            "value": "2015-07-30",
            "description": "The publication date for the initial version of this document."
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            "description": "The publication date for the document."
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            "name": "status",
            "value": "Active",
            "description": "Whether this document is Active or Deprecated within moalmanac-db."
          }
        ]
      }
    }
  ]
}