{
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    "message": "Indication id ind:ema.opdivo:1 retrieved successfully",
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    "timestamp_received": "2026-03-16T05:50:27.023649+00:00Z",
    "timestamp_returned": "2026-03-16T05:50:27.027960+00:00Z",
    "trace_id": "078af8d1-eedd-4058-97d0-cd6b44cf1dc4"
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    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-03-05"
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  "data": [
    {
      "id": "ind:ema.opdivo:1",
      "indication": "OPDIVO in combination with platinum-based chemotherapy is indicated for the neoadjuvant treatment of resectable non-small cell lung cancer at high risk of recurrence in adult patients whose tumours have PD-L1 expression >= 1%.",
      "initial_approval_date": "2023-07-18",
      "initial_approval_url": "https://www.ema.europa.eu/en/documents/variation-report/opdivo-h-c-003985-ii-0117-epar-assessment-report-variation_en.pdf",
      "description": "The European Medicines Agency (EMA) has authorized nivolumab in combination with platinum-based chemotherapy for the neoadjuvant treatment of adult patients with resectable non-small cell lung cancer at high risk of recurrence whose tumors haev PD-L1 expression >= 1%. This indication is based on CA209816, a randomized, open-label, phase 3 study where the selection of platinum-based chemotherapy was investigator's choice of paclitaxel and carboplatin, pemetrexed and cisplatin, or gemcitabine and cisplatin.",
      "raw_biomarkers": null,
      "raw_cancer_type": "Non-small cell lung cancer",
      "raw_therapeutics": "Opdivo (nivolumab) in combination with platinum-based chemotherapy",
      "icd10": null,
      "regimen_code": null,
      "reimbursement_category": null,
      "reimbursement_date": null,
      "reimbursement_details": null,
      "date_regular_approval": null,
      "date_accelerated_approval": null,
      "document": {
        "id": "doc:ema.opdivo",
        "type": "Document",
        "documentType": "Regulatory approval",
        "name": "Opdivo (nivolumab) [product information]. EMA.",
        "title": null,
        "aliases": [],
        "description": "Bristol-Myers Squibb Pharma EEIG. Opdivo (nivolumab) [product information]. European Medicines Agency website. https://www.ema.europa.eu/en/documents/product-information/opdivo-epar-product-information_en.pdf. Revised June 2025. Accessed September 5, 2025.",
        "urls": [
          "https://www.ema.europa.eu/en/medicines/human/EPAR/opdivo",
          "https://www.ema.europa.eu/en/documents/product-information/opdivo-epar-product-information_en.pdf"
        ],
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        "pmid": null,
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              "type": "Agent",
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              "name": "European Medicines Agency",
              "description": "Regulatory agency that approves medicines for use in the European Union.",
              "extensions": [
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                  "value": "2025-10-01",
                  "description": ""
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                  "value": "https://www.ema.europa.eu/en/medicines",
                  "description": ""
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            },
            "description": "The organization that published this document."
          },
          {
            "name": "company",
            "value": "Bristol-Myers Squibb Pharma EEIG.",
            "description": "The company that manufactures the cancer drug. Only applicable to market authorization documents."
          },
          {
            "name": "drug_name_brand",
            "value": "Opdivo",
            "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
          },
          {
            "name": "drug_name_generic",
            "value": "nivolumab",
            "description": "The generic name of the cancer drug, per this document. Only applicable to market authorization documents."
          },
          {
            "name": "first_publication_date",
            "value": "2015-07-16",
            "description": "The publication date for the initial version of this document."
          },
          {
            "name": "identification_number",
            "value": null,
            "description": "Identification number used by the publishing organization."
          },
          {
            "name": "publication_date",
            "value": "2025-06-02",
            "description": "The publication date for the document."
          },
          {
            "name": "status",
            "value": "Active",
            "description": "Whether this document is Active or Deprecated within moalmanac-db."
          }
        ]
      }
    }
  ]
}