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    "name": "Molecular Oncology Almanac",
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    {
      "id": "ind:ema.tremelimumab-astrazeneca:0",
      "indication": "Tremelimumab AstraZeneca in combination with durvalumab and platinum-based chemotherapy is indicated for the first-line treatment of adults with metastatic non-small cell lung cancer (NSCLC) with no sensitising EGFR mutations or ALK positive mutations.",
      "initial_approval_date": "2023-04-04",
      "initial_approval_url": "https://www.ema.europa.eu/en/documents/assessment-report/tremelimumab-astrazeneca-epar-public-assessment-report_en.pdf",
      "description": "The European Medicines Agency (EMA) has authorized tremelimumab in combination with durvalumab and platinum-based chemotherapy for the first-line treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) with no sensitizing EGFR mutations or ALK-positive mutations. This indication is based on POSEIDON, a randomized, open-label, and multicenter study where patients received one of the following chemotherapy regimes: Pemetrexed in combination with carboplatin or cisplatin for patients with non-squamous NSCLC, gemcitabine with cisplatin or carboplatin for patients with squamous NSCLC, and nab-paclitaxel with carboplatin for either non-squamous or squamous NSCLC.",
      "raw_biomarkers": null,
      "raw_cancer_type": "Non-small cell lung cancer",
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      "icd10": null,
      "regimen_code": null,
      "reimbursement_category": null,
      "reimbursement_date": null,
      "reimbursement_details": null,
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      "date_accelerated_approval": null,
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        "id": "doc:ema.tremelimumab-astrazeneca",
        "type": "Document",
        "documentType": "Regulatory approval",
        "name": "Tremelimumab AstraZeneca (tremelimumab) [product information]. EMA.",
        "title": null,
        "aliases": [],
        "description": "AstraZeneca AB. Tremelimumab AstraZeneca (tremelimumab) [product information]. European Medicines Agency website. https://www.ema.europa.eu/en/documents/product-information/tremelimumab-astrazeneca-epar-product-information_en.pdf. Revised September 2023. Accessed March 25, 2024.",
        "urls": [
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          "https://www.ema.europa.eu/en/documents/product-information/tremelimumab-astrazeneca-epar-product-information_en.pdf"
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        "pmid": null,
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                  "name": "last_updated",
                  "value": "2025-10-01",
                  "description": ""
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                  "value": "https://www.ema.europa.eu/en/medicines",
                  "description": ""
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            "description": "The organization that published this document."
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          {
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            "value": "AstraZeneca AB.",
            "description": "The company that manufactures the cancer drug. Only applicable to market authorization documents."
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            "value": "Tremelimumab AstraZeneca",
            "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
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            "description": "The publication date for the document."
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            "name": "status",
            "value": "Deprecated",
            "description": "Whether this document is Active or Deprecated within moalmanac-db."
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}