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    "name": "Molecular Oncology Almanac",
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  "data": [
    {
      "id": "ind:ema.yervoy:0",
      "indication": "YERVOY in combination with nivolumab and 2 cycles of platinum-based chemotherapy is indicated for the first-line treatment of metastatic non-small cell lung cancer in adults whose tumours have no sensitising EGFR mutation or ALK translocation.",
      "initial_approval_date": "2020-11-20",
      "initial_approval_url": "https://www.ema.europa.eu/en/documents/variation-report/yervoy-h-c-ws-1783-epar-assessment-report-variation_en.pdf",
      "description": "The European Medicines Agency (EMA) has authorized ipilimumab in combination with nivolumab and 2 cycles of platinum-based chemotherapy for the first-line treatment of adult patients with metastatic non-small cell lung cancer whose tumors have no sensitizing EGFR mutations or ALK translocations. This indication is based on CA2099LA, a phase 3, randomized, and open-label study in which the platinum-based chemotherapy was either carboplatin and pemetrexed or cisplatin and pemetrexed for non-squamous NSCLC, or carboplatin and paclitaxel for squamous NSCLC.",
      "raw_biomarkers": null,
      "raw_cancer_type": "Non-small cell lung cancer",
      "raw_therapeutics": "Yervoy (ipilimumab) in combination with nivolumab and 2 cycles of platinum-based chemotherapy",
      "icd10": null,
      "regimen_code": null,
      "reimbursement_category": null,
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      "reimbursement_details": null,
      "date_regular_approval": null,
      "date_accelerated_approval": null,
      "document": {
        "id": "doc:ema.yervoy",
        "type": "Document",
        "documentType": "Regulatory approval",
        "name": "Yervoy (ipilimumab) [product information]. EMA.",
        "title": null,
        "aliases": [],
        "description": "Bristol-Myers Squibb Pharma EEIG. Yervoy (ipilimumab) [product information]. European Medicines Agency website. https://www.ema.europa.eu/en/documents/product-information/yervoy-epar-product-information_en.pdf. Revised March 2025. Accessed September 5, 2025.",
        "urls": [
          "https://www.ema.europa.eu/en/medicines/human/EPAR/yervoy",
          "https://www.ema.europa.eu/en/documents/product-information/yervoy-epar-product-information_en.pdf"
        ],
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        "pmid": null,
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              "type": "Agent",
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              "name": "European Medicines Agency",
              "description": "Regulatory agency that approves medicines for use in the European Union.",
              "extensions": [
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                  "value": "2025-10-01",
                  "description": ""
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                {
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                  "value": "https://www.ema.europa.eu/en/medicines",
                  "description": ""
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            "description": "The organization that published this document."
          },
          {
            "name": "company",
            "value": "Bristol-Myers Squibb Pharma EEIG.",
            "description": "The company that manufactures the cancer drug. Only applicable to market authorization documents."
          },
          {
            "name": "drug_name_brand",
            "value": "Yervoy",
            "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
          },
          {
            "name": "drug_name_generic",
            "value": "ipilimumab",
            "description": "The generic name of the cancer drug, per this document. Only applicable to market authorization documents."
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          {
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            "value": "2011-07-25",
            "description": "The publication date for the initial version of this document."
          },
          {
            "name": "identification_number",
            "value": null,
            "description": "Identification number used by the publishing organization."
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          {
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            "value": "2025-03-17",
            "description": "The publication date for the document."
          },
          {
            "name": "status",
            "value": "Active",
            "description": "Whether this document is Active or Deprecated within moalmanac-db."
          }
        ]
      }
    }
  ]
}