{
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    "timestamp_received": "2026-09-25T01:15:08.891943+00:00Z",
    "timestamp_returned": "2026-09-25T01:15:08.893624+00:00Z",
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    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
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  "data": [
    {
      "id": "ind:fda:komzifti:0",
      "type": "Indication",
      "description": "KOMZIFTI is a menin inhibitor indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with a susceptible nucleophosmin 1 (NPM1) mutation who have no satisfactory alterantive treatment options.",
      "contributions": [
        {
          "id": "ctrb:vanallenlab:2025-12-23:1",
          "type": "Contribution",
          "description": "On 2025-11-13, the US FDA granted regular approval to ziftomenib for the treatment of patients with relapsed or refractory acute myeloid leukemia (AML) with susceptible NPM1 mutation who have no satisfactory alternative treatment options.",
          "date": "2025-12-23",
          "contributor": {
            "id": "agent:user:vanallenlab",
            "type": "Agent",
            "agentType": "contributor",
            "name": "Van Allen lab",
            "description": "Van Allen lab, Dana-Farber Cancer Institute"
          }
        },
        {
          "id": "ctrb:fda:2025-11-13:0",
          "type": "Contribution",
          "description": "Indication received traditional approval.",
          "date": "2025-11-13",
          "contributor": {
            "id": "agent:org:fda",
            "type": "Agent",
            "agentType": "organization",
            "name": "Food and Drug Administration",
            "description": "Regulatory agency that approves drugs for use in the United States."
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      "reportedIn": [
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          "id": "doc:fda:komzifti",
          "type": "Document",
          "documentType": "Regulatory approval",
          "name": "Komzifti (ziftomenib) [package insert]. FDA.",
          "title": null,
          "aliases": [],
          "description": "Kura Oncology, Inc. Komzifti (ziftomenib) [package insert]. U.S. Food and Drug Administration website. https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/220305s000lbl.pdf. Revised November 2025. Accessed December 23, 2025.",
          "urls": [
            "https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/220305s000lbl.pdf",
            "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=220305"
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          "pmid": null,
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              "description": "The organization that published this document."
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            {
              "name": "company",
              "value": "Kura Oncology, Inc",
              "description": "The company that manufactures the cancer drug. Only applicable to market authorization documents."
            },
            {
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              "value": "Komzifti",
              "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
            },
            {
              "name": "drug_name_generic",
              "value": "ziftomenib",
              "description": "The generic name of the cancer drug, per this document. Only applicable to market authorization documents."
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              "value": "2025-11-13",
              "description": "The publication date for the initial version of this document."
            },
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              "value": 220305,
              "description": "Identification number used by the publishing organization."
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            {
              "name": "publication_date",
              "value": "2025-11-13",
              "description": "The publication date for the document."
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              "value": "Active",
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        }
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}