{
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    "data_length": 1,
    "message": "Indication id ind:hc.giotrif:0 retrieved successfully",
    "request_url": "http://api.moalmanac.org/indications?indication_id=ind%3Ahc.giotrif%3A0",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.003603,
    "timestamp_received": "2026-04-06T14:51:52.965376+00:00Z",
    "timestamp_returned": "2026-04-06T14:51:52.968979+00:00Z",
    "trace_id": "9b4c1994-0c04-4c23-b96f-0a00a58c539f"
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  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-03-05"
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  "data": [
    {
      "id": "ind:hc.giotrif:0",
      "indication": "GIOTRIF (afatinib) is indicated as monotherapy for the treatment of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitor naïve patients with metastatic adenocarcinoma of the lung with activating EGFR mutation(s).",
      "initial_approval_date": null,
      "initial_approval_url": null,
      "description": "Health Canada approved afatinib for the treatment of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitor naïve patients with metastatic adenocarcinoma of the lung with activating EGFR mutation(s).",
      "raw_biomarkers": "EGFR Del 19, EGFR exon 21 L858R",
      "raw_cancer_type": "metastatic adenocarcinoma of the lung",
      "raw_therapeutics": "Giotrif (afatinib)",
      "icd10": null,
      "regimen_code": null,
      "reimbursement_category": null,
      "reimbursement_date": null,
      "reimbursement_details": null,
      "date_regular_approval": null,
      "date_accelerated_approval": null,
      "document": {
        "id": "doc:hc.giotrif",
        "type": "Document",
        "documentType": "Regulatory approval",
        "name": "Giotrif (afatinib) [product monograph]. HC.",
        "title": null,
        "aliases": [],
        "description": "Boehringer Ingelheim (Canada) Ltd. Giotrif (afatinib) [product monograph]. Health Canada website. https://pdf.hres.ca/dpd_pm/00051644.PDF. Revised June 2019. Accessed June 2025.",
        "urls": [
          "https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=90026",
          "https://pdf.hres.ca/dpd_pm/00051644.PDF"
        ],
        "doi": null,
        "pmid": null,
        "extensions": [
          {
            "name": "agent",
            "value": {
              "id": "hc",
              "type": "Agent",
              "agentType": "organization",
              "name": "Health Canada",
              "description": "Regulatory agency that approves drugs for sale and use in Canada.",
              "extensions": [
                {
                  "name": "last_updated",
                  "value": "2025-06-11",
                  "description": ""
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                {
                  "name": "url",
                  "value": "https://health-products.canada.ca/dpd-bdpp/",
                  "description": ""
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            "description": "The organization that published this document."
          },
          {
            "name": "company",
            "value": "Boehringer Ingelheim (Canada) Ltd",
            "description": "The company that manufactures the cancer drug. Only applicable to market authorization documents."
          },
          {
            "name": "drug_name_brand",
            "value": "Giotrif",
            "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
          },
          {
            "name": "drug_name_generic",
            "value": "afatinib",
            "description": "The generic name of the cancer drug, per this document. Only applicable to market authorization documents."
          },
          {
            "name": "first_publication_date",
            "value": null,
            "description": "The publication date for the initial version of this document."
          },
          {
            "name": "identification_number",
            "value": null,
            "description": "Identification number used by the publishing organization."
          },
          {
            "name": "publication_date",
            "value": "2019-06-06",
            "description": "The publication date for the document."
          },
          {
            "name": "status",
            "value": "Active",
            "description": "Whether this document is Active or Deprecated within moalmanac-db."
          }
        ]
      }
    }
  ]
}