{
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    "message": "Indication id ind:hc.iclusig:1 retrieved successfully",
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    "timestamp_received": "2026-04-06T14:51:53.066342+00:00Z",
    "timestamp_returned": "2026-04-06T14:51:53.070213+00:00Z",
    "trace_id": "ca3d69e4-6cfc-43cb-930a-e62ac055b7fb"
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    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-03-05"
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  "data": [
    {
      "id": "ind:hc.iclusig:1",
      "indication": "ICLUSIG (ponatinib tablets) is indicated for the treatment of adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) for whom other tyrosine kinase inhibitor (TKI) therapy is not appropriate, including Ph+ ALL that is T315I mutation positive or where there is prior TKI resistance or intolerance",
      "initial_approval_date": null,
      "initial_approval_url": null,
      "description": "Health Canada approved ponatinib for the treatment of adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) who are not appropriate for other tyrosine kinase inhibitor (TKI) therapy, including those with the T315I mutation or prior TKI resistance or intolerance.",
      "raw_biomarkers": "Philadelphia chromosome positive, T315I mutation positive",
      "raw_cancer_type": "acute lymphoblastic leukemia (Ph+ ALL)",
      "raw_therapeutics": "Iclusig (ponatinib)",
      "icd10": null,
      "regimen_code": null,
      "reimbursement_category": null,
      "reimbursement_date": null,
      "reimbursement_details": null,
      "date_regular_approval": null,
      "date_accelerated_approval": null,
      "document": {
        "id": "doc:hc.iclusig",
        "type": "Document",
        "documentType": "Regulatory approval",
        "name": "Iclusig (ponatinib) [product monograph]. HC.",
        "title": null,
        "aliases": [],
        "description": "Takeda Pharmaceuticals U.S.A., Inc. Iclusig (ponatinib) [product monograph]. Health Canada website. https://pdf.hres.ca/dpd_pm/00078669.PDF. Revised February. Accessed June 2025.",
        "urls": [
          "https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=92168",
          "https://pdf.hres.ca/dpd_pm/00078669.PDF"
        ],
        "doi": null,
        "pmid": null,
        "extensions": [
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            "value": {
              "id": "hc",
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              "agentType": "organization",
              "name": "Health Canada",
              "description": "Regulatory agency that approves drugs for sale and use in Canada.",
              "extensions": [
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                  "name": "last_updated",
                  "value": "2025-06-11",
                  "description": ""
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                  "name": "url",
                  "value": "https://health-products.canada.ca/dpd-bdpp/",
                  "description": ""
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            "description": "The organization that published this document."
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          {
            "name": "company",
            "value": "Takeda Pharmaceuticals U.S.A., Inc.",
            "description": "The company that manufactures the cancer drug. Only applicable to market authorization documents."
          },
          {
            "name": "drug_name_brand",
            "value": "Iclusig",
            "description": "The brand name of the cancer drug, per this document. Only applicable to market authorization documents."
          },
          {
            "name": "drug_name_generic",
            "value": "ponatinib",
            "description": "The generic name of the cancer drug, per this document. Only applicable to market authorization documents."
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          {
            "name": "first_publication_date",
            "value": "2015-03-31",
            "description": "The publication date for the initial version of this document."
          },
          {
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            "value": null,
            "description": "Identification number used by the publishing organization."
          },
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            "name": "publication_date",
            "value": "2025-02-24",
            "description": "The publication date for the document."
          },
          {
            "name": "status",
            "value": "Active",
            "description": "Whether this document is Active or Deprecated within moalmanac-db."
          }
        ]
      }
    }
  ]
}