{
  "meta": {
    "data_length": 1,
    "message": "Proposition id 223 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=223",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.009305,
    "timestamp_received": "2026-04-23T20:26:54.343355+00:00Z",
    "timestamp_returned": "2026-04-23T20:26:54.352660+00:00Z",
    "trace_id": "b7f16826-055e-4a27-904c-65ea48b0cd63"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-04-09"
  },
  "data": [
    {
      "id": 223,
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictSensitivityTo",
      "biomarkers": [
        {
          "id": 48,
          "name": "BRCA1 pathogenic variants",
          "genes": [
            {
              "id": 9,
              "name": "BRCA1",
              "primaryCoding": {
                "id": "hgnc:1100",
                "code": "HGNC:1100",
                "name": null,
                "system": "https://genenames.org",
                "systemVersion": null,
                "iris": [
                  "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1100"
                ]
              },
              "mappings": [
                {
                  "relation": "relatedMatch",
                  "coding": {
                    "id": "refseq:NM_007294.4",
                    "code": "NM_007294.4",
                    "name": null,
                    "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                    "systemVersion": null,
                    "iris": [
                      "https://www.ncbi.nlm.nih.gov/nuccore/NM_007294.4"
                    ]
                  }
                },
                {
                  "relation": "exactMatch",
                  "coding": {
                    "id": "ensembl:ensg00000012048",
                    "code": "ENSG00000012048",
                    "name": null,
                    "system": "https://www.ensembl.org",
                    "systemVersion": null,
                    "iris": [
                      "https://www.ensembl.org/id/ENSG00000012048"
                    ]
                  }
                },
                {
                  "relation": "exactMatch",
                  "coding": {
                    "id": "ncbi:672",
                    "code": "672",
                    "name": null,
                    "system": "https://www.ncbi.nlm.nih.gov/gene",
                    "systemVersion": null,
                    "iris": [
                      "https://www.ncbi.nlm.nih.gov/gene/672"
                    ]
                  }
                }
              ],
              "extensions": [
                {
                  "name": "location",
                  "value": "17q21.31"
                },
                {
                  "name": "location_sortable",
                  "value": "17q21.31"
                }
              ]
            }
          ],
          "type": "CategoricalVariant",
          "extensions": [
            {
              "name": "biomarker_type",
              "value": "Germline Variant"
            },
            {
              "name": "present",
              "value": true
            },
            {
              "name": "chromosome",
              "value": "17"
            },
            {
              "name": "requires_pathogenic",
              "value": true
            }
          ]
        }
      ],
      "subjectVariant": {},
      "conditionQualifier": {
        "id": 51,
        "conceptType": "Disease",
        "name": "Ovarian Epithelial Tumor",
        "primaryCoding": {
          "id": "oncotree:OVT",
          "code": "OVT",
          "name": "Ovarian Epithelial Tumor",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=OVT"
          ]
        },
        "mappings": []
      },
      "objectTherapeutic": {
        "id": 6,
        "conceptType": "Drug",
        "name": "Niraparib",
        "primaryCoding": {
          "id": "ncit:C80059",
          "code": "C80059",
          "name": "Niraparib",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C80059"
          ]
        },
        "mappings": [],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "PARP inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ]
      }
    }
  ]
}