{
  "meta": {
    "data_length": 1,
    "message": "Proposition id 339 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=339",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.009031,
    "timestamp_received": "2026-06-08T21:12:41.016746+00:00Z",
    "timestamp_returned": "2026-06-08T21:12:41.025777+00:00Z",
    "trace_id": "6757d130-fd66-4b26-a118-d07ac716767b"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-05-07"
  },
  "data": [
    {
      "id": 339,
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictSensitivityTo",
      "biomarkers": [
        {
          "id": 42,
          "name": "PD-L1 (CPS) >= 1",
          "genes": [],
          "type": "CategoricalVariant",
          "extensions": [
            {
              "name": "biomarker_type",
              "value": "Protein expression"
            },
            {
              "name": "present",
              "value": true
            },
            {
              "name": "marker",
              "value": "PD-L1"
            },
            {
              "name": "unit",
              "value": "Combined Positive Score (CPS)"
            },
            {
              "name": "equality",
              "value": ">="
            },
            {
              "name": "value",
              "value": "1"
            }
          ]
        }
      ],
      "subjectVariant": {},
      "conditionQualifier": {
        "id": 72,
        "conceptType": "Disease",
        "name": "Cervical Adenocarcinoma",
        "primaryCoding": {
          "id": "oncotree:CEAD",
          "code": "CEAD",
          "name": "Cervical Adenocarcinoma",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=CEAD"
          ]
        },
        "mappings": []
      },
      "objectTherapeutic": {
        "id": 48,
        "conceptType": "Drug",
        "name": "Pembrolizumab",
        "primaryCoding": {
          "id": "ncit:C106432",
          "code": "C106432",
          "name": "Pembrolizumab",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C106432"
          ]
        },
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "rxcui:1547545",
              "code": "1547545",
              "name": "pembrolizumab",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1547545"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "omop:45775965",
              "code": "45775965",
              "name": "pembrolizumab",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/45775965"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "sctid:716125002",
              "code": "716125002",
              "name": "Pembrolizumab",
              "system": "SNOMED",
              "systemVersion": "2025-03-01",
              "iris": [
                "https://browser.ihtsdotools.org/?perspective=full&conceptId1=716125002&edition=MAIN/2025-03-01&release=&languages=en"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "omop:37396350",
              "code": "37396350",
              "name": "Pembrolizumab",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/37396350"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "PD-1/PD-L1 inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Immunotherapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ]
      }
    }
  ]
}