{
  "meta": {
    "data_length": 1,
    "message": "Proposition id 378 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=378",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.007303,
    "timestamp_received": "2026-04-23T21:45:21.346328+00:00Z",
    "timestamp_returned": "2026-04-23T21:45:21.353631+00:00Z",
    "trace_id": "d22f3414-07e2-493d-bc3c-857e7043d96d"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-04-09"
  },
  "data": [
    {
      "id": 378,
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictSensitivityTo",
      "biomarkers": [
        {
          "id": 54,
          "name": "CD20 +",
          "genes": [],
          "type": "CategoricalVariant",
          "extensions": [
            {
              "name": "biomarker_type",
              "value": "Protein expression"
            },
            {
              "name": "present",
              "value": true
            },
            {
              "name": "marker",
              "value": "CD20"
            },
            {
              "name": "unit",
              "value": "status"
            },
            {
              "name": "equality",
              "value": "="
            },
            {
              "name": "value",
              "value": "Positive"
            }
          ]
        }
      ],
      "subjectVariant": {},
      "conditionQualifier": {
        "id": 76,
        "conceptType": "Disease",
        "name": "Non-Hodgkin Lymphoma",
        "primaryCoding": {
          "id": "oncotree:NHL",
          "code": "NHL",
          "name": "Non-Hodgkin Lymphoma",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=NHL"
          ]
        },
        "mappings": []
      },
      "objectTherapeutic": {
        "id": 60,
        "conceptType": "Drug",
        "name": "Rituximab",
        "primaryCoding": {
          "id": "ncit:C1702",
          "code": "C1702",
          "name": "Rituximab",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1702"
          ]
        },
        "mappings": [],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "CD20 inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Immunotherapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ]
      }
    }
  ]
}