{
  "meta": {
    "data_length": 1,
    "message": "Proposition id 584 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=584",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.012503,
    "timestamp_received": "2026-06-08T20:00:27.256805+00:00Z",
    "timestamp_returned": "2026-06-08T20:00:27.269308+00:00Z",
    "trace_id": "b45173e7-4a4e-4772-a11a-811c40c58f0b"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-05-07"
  },
  "data": [
    {
      "id": 584,
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictSensitivityTo",
      "biomarkers": [
        {
          "id": 33,
          "name": "PD-L1 >= 1%",
          "genes": [],
          "type": "CategoricalVariant",
          "extensions": [
            {
              "name": "biomarker_type",
              "value": "Protein expression"
            },
            {
              "name": "present",
              "value": true
            },
            {
              "name": "marker",
              "value": "PD-L1"
            },
            {
              "name": "unit",
              "value": "Tumor Proportion Score (TPS)"
            },
            {
              "name": "equality",
              "value": ">="
            },
            {
              "name": "value",
              "value": "0.01"
            }
          ]
        }
      ],
      "subjectVariant": {},
      "conditionQualifier": {
        "id": 47,
        "conceptType": "Disease",
        "name": "Non-Small Cell Lung Cancer",
        "primaryCoding": {
          "id": "oncotree:NSCLC",
          "code": "NSCLC",
          "name": "Non-Small Cell Lung Cancer",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=NSCLC"
          ]
        },
        "mappings": []
      },
      "objectTherapeutic": {
        "id": 44,
        "conceptType": "Drug",
        "name": "Durvalumab",
        "primaryCoding": {
          "id": "ncit:C103194",
          "code": "C103194",
          "name": "Durvalumab",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C103194"
          ]
        },
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "rxcui:1919503",
              "code": "1919503",
              "name": "durvalumab",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1919503"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "omop:1594034",
              "code": "1594034",
              "name": "durvalumab",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/1594034"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "sctid:735230005",
              "code": "735230005",
              "name": "Durvalumab",
              "system": "SNOMED",
              "systemVersion": "2025-03-01",
              "iris": [
                "https://browser.ihtsdotools.org/?perspective=full&conceptId1=735230005&edition=MAIN/2025-03-01&release=&languages=en"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "omop:42536415",
              "code": "42536415",
              "name": "Durvalumab",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/42536415"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "PD-1/PD-L1 inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Immunotherapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ]
      }
    }
  ]
}