{
  "meta": {
    "data_length": 1,
    "message": "Proposition id 773 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=773",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.007593,
    "timestamp_received": "2026-04-23T21:44:36.733853+00:00Z",
    "timestamp_returned": "2026-04-23T21:44:36.741446+00:00Z",
    "trace_id": "09cf1b1a-112e-47e0-80dc-8baadd44081b"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-04-09"
  },
  "data": [
    {
      "id": 773,
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictSensitivityTo",
      "biomarkers": [
        {
          "id": 20,
          "name": "HER2-positive",
          "genes": [],
          "type": "CategoricalVariant",
          "extensions": [
            {
              "name": "biomarker_type",
              "value": "Protein expression"
            },
            {
              "name": "present",
              "value": true
            },
            {
              "name": "marker",
              "value": "Human epidermal growth factor receptor 2 (HER2)"
            },
            {
              "name": "unit",
              "value": "status"
            },
            {
              "name": "equality",
              "value": "="
            },
            {
              "name": "value",
              "value": "Positive"
            }
          ]
        },
        {
          "id": 3,
          "name": "PR positive",
          "genes": [],
          "type": "CategoricalVariant",
          "extensions": [
            {
              "name": "biomarker_type",
              "value": "Protein expression"
            },
            {
              "name": "present",
              "value": true
            },
            {
              "name": "marker",
              "value": "Progesterone receptor (PR)"
            },
            {
              "name": "unit",
              "value": "status"
            },
            {
              "name": "equality",
              "value": "="
            },
            {
              "name": "value",
              "value": "Positive"
            }
          ]
        },
        {
          "id": 1,
          "name": "ER positive",
          "genes": [],
          "type": "CategoricalVariant",
          "extensions": [
            {
              "name": "biomarker_type",
              "value": "Protein expression"
            },
            {
              "name": "present",
              "value": true
            },
            {
              "name": "marker",
              "value": "Estrogen receptor (ER)"
            },
            {
              "name": "unit",
              "value": "status"
            },
            {
              "name": "equality",
              "value": "="
            },
            {
              "name": "value",
              "value": "Positive"
            }
          ]
        }
      ],
      "subjectVariant": {},
      "conditionQualifier": {
        "id": 9,
        "conceptType": "Disease",
        "name": "Invasive Breast Carcinoma",
        "primaryCoding": {
          "id": "oncotree:BRCA",
          "code": "BRCA",
          "name": "Invasive Breast Carcinoma",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=BRCA"
          ]
        },
        "mappings": []
      },
      "objectTherapeutic": {
        "id": 36,
        "conceptType": "Drug",
        "name": "Anastrozole",
        "primaryCoding": {
          "id": "ncit:C1607",
          "code": "C1607",
          "name": "Anastrozole",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1607"
          ]
        },
        "mappings": [],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "Aromatase inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Hormone therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ]
      }
    }
  ]
}