{
  "meta": {
    "data_length": 1,
    "message": "Proposition id 840 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=840",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.006696,
    "timestamp_received": "2026-04-24T15:53:11.812252+00:00Z",
    "timestamp_returned": "2026-04-24T15:53:11.818948+00:00Z",
    "trace_id": "0982db73-4553-40b6-84ca-4e090fe261b9"
  },
  "service": {
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    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-04-09"
  },
  "data": [
    {
      "id": 840,
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictSensitivityTo",
      "biomarkers": [
        {
          "id": 172,
          "name": "t(15;17)",
          "genes": [],
          "type": "CategoricalVariant",
          "extensions": [
            {
              "name": "biomarker_type",
              "value": "Rearrangement"
            },
            {
              "name": "present",
              "value": true
            },
            {
              "name": "rearrangement_type",
              "value": "Translocation"
            }
          ]
        }
      ],
      "subjectVariant": {},
      "conditionQualifier": {
        "id": 10,
        "conceptType": "Disease",
        "name": "APL with PML-RARA",
        "primaryCoding": {
          "id": "oncotree:APLPMLRARA",
          "code": "APLPMLRARA",
          "name": "APL with PML-RARA",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=APLPMLRARA"
          ]
        },
        "mappings": []
      },
      "objectTherapeutic": {
        "id": 93,
        "conceptType": "Drug",
        "name": "Arsenic trioxide",
        "primaryCoding": {
          "id": "ncit:C1005",
          "code": "C1005",
          "name": "Arsenic Trioxide",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1005"
          ]
        },
        "mappings": [],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "PML::RARA inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ]
      }
    }
  ]
}