{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:126 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A126", "status": "success", "status_code": 200, "timestamp_elapsed": 0.0019, "timestamp_received": "2026-09-25T01:16:25.866142+00:00Z", "timestamp_returned": "2026-09-25T01:16:25.868042+00:00Z", "trace_id": "34ce404e-3568-4741-8f3f-2ac5b45a3ac0" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:126", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:BLCA", "conceptType": "Disease", "name": "Bladder Urothelial Carcinoma", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:BLCA", "code": "BLCA", "name": "Bladder Urothelial Carcinoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=BLCA" ] } }, "objectTherapeutic": { "id": "tx:ncit:C103273", "conceptType": "Therapy", "name": "Erdafitinib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2123125", "code": "2123125", "name": "erdafitinib", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2123125" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1511250", "code": "1511250", "name": "erdafitinib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1511250" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:787731007", "code": "787731007", "name": "Erdafitinib", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=787731007&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:37204108", "code": "37204108", "name": "Erdafitinib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/37204108" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "FGFR inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C103273", "code": "C103273", "name": "Erdafitinib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C103273" ] } }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:101", "present": true, "subject": { "id": "bmkr:101", "type": "CategoricalVariant", "name": "FGFR3 p.G370C", "constraints": [ { "type": "DefiningAlleleConstraint", "allele": { "id": "ga4gh:VA.jN7GBCtzW-TeO8Oj6sXOTBkb5RpqsnhE", "type": "Allele", "name": "NP_000133.1:p.Gly370Cys", "aliases": [ "NP_000133.1:p.G370C", "FGFR3 p.G370C" ], "description": "VRS variation of NP_000133.1:p.Gly370Cys", "digest": "jN7GBCtzW-TeO8Oj6sXOTBkb5RpqsnhE", "expressions": [ { "syntax": "hgvs.p", "value": "NP_000133.1:p.Gly370Cys", "extensions": [ { "name": "hgvs.p_short", "value": "p.G370C" } ] } ], "location": { "id": "ga4gh:SL.BWL7lNkUDNtm3WnoyGpB-q0-58XpHTxt", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Amino acid position 370 of the Refseq protein NP_000133.1, which is the protein product of the MANE Select coding transcript for FGFR3 (refseq:NM_000142.5).", "digest": "BWL7lNkUDNtm3WnoyGpB-q0-58XpHTxt", "sequenceReference": { "id": "ga4gh:SQ.xO86teDIIalLkqprCQaXyuvdPqvBxBG3", "type": "SequenceReference", "name": "NP_000133.1", "aliases": [ "ensembl:ENSP00000260795.2", "ga4gh:SQ.xO86teDIIalLkqprCQaXyuvdPqvBxBG3", "refseq:NP_000133.1" ], "description": "The protein product of the MANE Select coding transcript for FGFR3 (refseq:NM_000142.5), corresponding to the Refseq protein accession NP_000133.1.", "moleculeType": "protein", "refgetAccession": "SQ.xO86teDIIalLkqprCQaXyuvdPqvBxBG3", "residueAlphabet": "aa" }, "start": 369, "end": 370, "sequence": "G" }, "state": { "type": "LiteralSequenceExpression", "sequence": "C" } }, "relations": [] }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:3690", "conceptType": "Gene", "name": "FGFR3", "primaryCoding": { "id": "coding:hgnc:3690", "code": "HGNC:3690", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3690" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000068078", "code": "ENSG00000068078", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000068078" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:2261", "code": "2261", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/2261" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_000142.5", "code": "NM_000142.5", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_000142.5" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "4" }, { "name": "start_position", "value": 1806089 }, { "name": "end_position", "value": 1806089 }, { "name": "reference_allele", "value": "G" }, { "name": "alternate_allele", "value": "T" }, { "name": "cdna_change", "value": "c.1108G>T" }, { "name": "protein_change", "value": "p.G370C" }, { "name": "variant_annotation", "value": "Missense" }, { "name": "exon", "value": 8 }, { "name": "rsid", "value": "rs121913479" }, { "name": "hgvsg", "value": "4:g.1806089G>T" }, { "name": "hgvsc", "value": "ENST00000260795.2:c.1108G>T" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }