{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:210 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A210", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001852, "timestamp_received": "2026-09-25T01:15:05.602341+00:00Z", "timestamp_returned": "2026-09-25T01:15:05.604193+00:00Z", "trace_id": "547c4f41-5037-4a49-b842-dd770e69a18d" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:210", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:AML", "conceptType": "Disease", "name": "Acute Myeloid Leukemia", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": false, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:AML", "code": "AML", "name": "Acute Myeloid Leukemia", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=AML" ] } }, "objectTherapeutic": { "id": "txgrp:40", "membershipOperator": "AND", "therapies": [ { "id": "tx:ncit:C408", "conceptType": "Therapy", "name": "Cytarabine", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:3041", "code": "3041", "name": "cytarabine", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ 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action of the therapy." }, { "name": "therapy_type", "value": "Chemotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C408", "code": "C408", "name": "Cytarabine", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C408" ] } }, { "id": "tx:ncit:C62091", "conceptType": "Therapy", "name": "Daunorubicin", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:3109", "code": "3109", "name": "daunorubicin", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3109" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1311799", "code": "1311799", "name": "daunorubicin", "system": "OMOP", "systemVersion": "v20260227", "iris": [ 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"code": "C62091", "name": "Daunorubicin", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62091" ] } }, { "id": "tx:ncit:C1872", "conceptType": "Therapy", "name": "Midostaurin", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:1919083", "code": "1919083", "name": "midostaurin", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1919083" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1594003", "code": "1594003", "name": "midostaurin", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1594003" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:763613005", "code": "763613005", "name": "Midostaurin", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=763613005&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:35622245", "code": "35622245", "name": "Midostaurin", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/35622245" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "FLT3 inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C1872", "code": "C1872", "name": "Midostaurin", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1872" ] } } ] }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:116", "present": true, "subject": { "id": "bmkr:116", "type": "CategoricalVariant", "name": "FLT3 p.D835A", "constraints": [ { "type": "DefiningAlleleConstraint", "allele": { "id": "ga4gh:VA.3LKVcwmmyezzaaWmtcmAI63SZC5jSzMg", "type": "Allele", "name": "NP_004110.2:p.Asp835Ala", "aliases": [ "NP_004110.2:p.D835A", "FLT3 p.D835A" ], "description": "VRS variation of NP_004110.2:p.Asp835Ala", "digest": "3LKVcwmmyezzaaWmtcmAI63SZC5jSzMg", "expressions": [ { "syntax": "hgvs.p", "value": "NP_004110.2:p.Asp835Ala", "extensions": [ { "name": "hgvs.p_short", "value": "p.D835A" } ] } ], "location": { "id": "ga4gh:SL.2Tbt2D_8w_Jg3P2HhGEBwmwasbpLtfwP", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Amino acid position 835 of the Refseq protein NP_004110.2, which is the protein product of the MANE Select coding transcript for FLT3 (refseq:NM_004119.3).", "digest": "2Tbt2D_8w_Jg3P2HhGEBwmwasbpLtfwP", "sequenceReference": { "id": "ga4gh:SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH", "type": "SequenceReference", "name": "NP_004110.2", "aliases": [ "ensembl:ENSP00000241453.7", "ga4gh:SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH", "refseq:NP_004110.2" ], "description": "The protein product of the MANE Select coding transcript for FLT3 (refseq:NM_004119.3), corresponding to the Refseq protein accession NP_004110.2.", "moleculeType": "protein", "refgetAccession": "SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH", "residueAlphabet": "aa" }, "start": 834, "end": 835, "sequence": "D" }, "state": { "type": "LiteralSequenceExpression", "sequence": "A" } }, "relations": [] }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:3765", "conceptType": "Gene", "name": "FLT3", "primaryCoding": { "id": "coding:hgnc:3765", "code": "HGNC:3765", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3765" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000122025", "code": "ENSG00000122025", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000122025" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:2322", "code": "2322", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/2322" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_004119.3", "code": "NM_004119.3", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_004119.3" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "13" }, { "name": "start_position", "value": 28592641 }, { "name": "end_position", "value": 28592641 }, { "name": "reference_allele", "value": "T" }, { "name": "alternate_allele", "value": "G" }, { "name": "cdna_change", "value": "c.2504A>C" }, { "name": "protein_change", "value": "p.D835A" }, { "name": "variant_annotation", "value": "Missense" }, { "name": "exon", "value": 20 }, { "name": "rsid", "value": "rs121909646" }, { "name": "hgvsg", "value": "13:g.28592641T>G" }, { "name": "hgvsc", "value": "ENST00000241453.7:c.2504A>C" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }