{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:248 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A248", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001846, "timestamp_received": "2026-09-25T00:12:30.789771+00:00Z", "timestamp_returned": "2026-09-25T00:12:30.791617+00:00Z", "trace_id": "8ac7f507-f353-482f-92fb-da46dcd5ef50" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:248", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:HGSFT", "conceptType": "Disease", "name": "High-Grade Serous Fallopian Tube Cancer", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:HGSFT", "code": "HGSFT", "name": "High-Grade Serous Fallopian Tube Cancer", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=HGSFT" ] } }, "objectTherapeutic": { "id": "txgrp:43", "membershipOperator": "AND", "therapies": [ { "id": "tx:ncit:C2039", "conceptType": "Therapy", "name": "Bevacizumab", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:253337", "code": "253337", "name": "bevacizumab", "system": "RxNorm", "systemVersion": 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mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C2039", "code": "C2039", "name": "Bevacizumab", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2039" ] } }, { "id": "tx:ncit:C71721", "conceptType": "Therapy", "name": "Olaparib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:1597582", "code": "1597582", "name": "olaparib", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1597582" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:45892579", "code": "45892579", "name": "olaparib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/45892579" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:432162002", "code": "432162002", "name": "Olaparib", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=432162002&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4332351", "code": "4332351", "name": "Olaparib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4332351" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "PARP inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C71721", "code": "C71721", "name": "Olaparib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C71721" ] } } ] }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:47", "present": true, "subject": { "id": "bmkr:47", "type": "CategoricalVariant", "name": "BRCA1 oncogenic variants", "constraints": [ { "type": "DefiningLocationConstraint", "location": { "id": "ga4gh:SL.weCy_6qoSvyzu7QVSpaJMaGWcDUKmqXb", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Sequence spanning the length of refseq:NP_009225.1, the protein product of the MANE Select coding transcript for BRCA1 (refseq:NM_007294.4).", "digest": "weCy_6qoSvyzu7QVSpaJMaGWcDUKmqXb", "sequenceReference": { "id": "ga4gh:SQ.nUzIPnHMyQV52hzgBbKl5vlbSwx8M8_Y", "type": "SequenceReference", "name": "NP_009225.1", "aliases": [ "ensembl:ENSP00000350283.3", "ga4gh:SQ.nUzIPnHMyQV52hzgBbKl5vlbSwx8M8_Y", "refseq:NP_009225.1" ], "description": "The protein product of the MANE Select coding transcript for BRCA1 (refseq:NM_007294.4), corresponding to the Refseq protein accession NP_009225.1.", "moleculeType": "protein", "refgetAccession": "SQ.nUzIPnHMyQV52hzgBbKl5vlbSwx8M8_Y", "residueAlphabet": "aa" }, "start": 0, "end": 1863, "sequence": null }, "relations": [], "matchCharacteristic": { "primaryCoding": { "code": "is_within", "system": "ga4gh-gks-term:location-match" } } }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:1100", "conceptType": "Gene", "name": "BRCA1", "primaryCoding": { "id": "coding:hgnc:1100", "code": "HGNC:1100", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1100" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000012048", "code": "ENSG00000012048", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000012048" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:672", "code": "672", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/672" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_007294.4", "code": "NM_007294.4", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_007294.4" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "17" }, { "name": "start_position", "value": null }, { "name": "end_position", "value": null }, { "name": "reference_allele", "value": null }, { "name": "alternate_allele", "value": null }, { "name": "cdna_change", "value": null }, { "name": "protein_change", "value": null }, { "name": "variant_annotation", "value": null }, { "name": "exon", "value": null }, { "name": "rsid", "value": null }, { "name": "hgvsg", "value": null }, { "name": "hgvsc", "value": null }, { "name": "requires_oncogenic", "value": true } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }