{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:28 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A28",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001837,
    "timestamp_received": "2026-09-25T00:12:26.701665+00:00Z",
    "timestamp_returned": "2026-09-25T00:12:26.703502+00:00Z",
    "trace_id": "1485905a-3c3a-4b52-9040-b4458fc51483"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:28",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:APLPMLRARA",
        "conceptType": "Disease",
        "name": "APL with PML-RARA",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": false,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:oncotree:APLPMLRARA",
          "code": "APLPMLRARA",
          "name": "APL with PML-RARA",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=APLPMLRARA"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C1005",
        "conceptType": "Therapy",
        "name": "Arsenic trioxide",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:18330",
              "code": "18330",
              "name": "arsenic trioxide",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=18330"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:1333379",
              "code": "1333379",
              "name": "arsenic trioxide",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/1333379"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:sctid:72251000",
              "code": "72251000",
              "name": "Arsenic trioxide",
              "system": "SNOMED",
              "systemVersion": "2025-03-01",
              "iris": [
                "https://browser.ihtsdotools.org/?perspective=full&conceptId1=72251000&edition=MAIN/2025-03-01&release=&languages=en"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:4218959",
              "code": "4218959",
              "name": "Arsenic trioxide",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/4218959"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "PML::RARA inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C1005",
          "code": "C1005",
          "name": "Arsenic Trioxide",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1005"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:79",
              "present": true,
              "subject": {
                "id": "bmkr:79",
                "type": "CategoricalVariant",
                "name": "PML::RARA",
                "constraints": [
                  {
                    "type": "AdjacencyConstraint",
                    "orderKnown": true,
                    "adjoinedElements": [
                      {
                        "id": "gene:hgnc:9113",
                        "conceptType": "Gene",
                        "name": "PML",
                        "primaryCoding": {
                          "id": "coding:hgnc:9113",
                          "code": "HGNC:9113",
                          "system": "https://genenames.org",
                          "iris": [
                            "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9113"
                          ]
                        },
                        "mappings": [
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ensembl:ensg00000140464",
                              "code": "ENSG00000140464",
                              "system": "https://www.ensembl.org",
                              "iris": [
                                "https://www.ensembl.org/id/ENSG00000140464"
                              ]
                            }
                          },
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ncbi:5371",
                              "code": "5371",
                              "system": "https://www.ncbi.nlm.nih.gov/gene",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/gene/5371"
                              ]
                            }
                          },
                          {
                            "relation": "relatedMatch",
                            "coding": {
                              "id": "coding:refseq:NM_033238.3",
                              "code": "NM_033238.3",
                              "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/nuccore/NM_033238.3"
                              ]
                            }
                          }
                        ]
                      },
                      {
                        "id": "gene:hgnc:9864",
                        "conceptType": "Gene",
                        "name": "RARA",
                        "primaryCoding": {
                          "id": "coding:hgnc:9864",
                          "code": "HGNC:9864",
                          "system": "https://genenames.org",
                          "iris": [
                            "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9864"
                          ]
                        },
                        "mappings": [
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ensembl:ensg00000131759",
                              "code": "ENSG00000131759",
                              "system": "https://www.ensembl.org",
                              "iris": [
                                "https://www.ensembl.org/id/ENSG00000131759"
                              ]
                            }
                          },
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ncbi:5914",
                              "code": "5914",
                              "system": "https://www.ncbi.nlm.nih.gov/gene",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/gene/5914"
                              ]
                            }
                          },
                          {
                            "relation": "relatedMatch",
                            "coding": {
                              "id": "coding:refseq:NM_000964.4",
                              "code": "NM_000964.4",
                              "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/nuccore/NM_000964.4"
                              ]
                            }
                          }
                        ]
                      }
                    ]
                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Gene fusion"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}