{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:358 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A358", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001916, "timestamp_received": "2026-09-25T00:12:26.981565+00:00Z", "timestamp_returned": "2026-09-25T00:12:26.983481+00:00Z", "trace_id": "eb8d6fb5-4644-48c5-9776-fba173b934fa" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:358", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:BRCA", "conceptType": "Disease", "name": "Invasive Breast Carcinoma", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:BRCA", "code": "BRCA", "name": "Invasive Breast Carcinoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=BRCA" ] } }, "objectTherapeutic": { "id": "txgrp:72", "membershipOperator": "AND", "therapies": [ { "id": "tx:ncit:C405", "conceptType": "Therapy", "name": "Cyclophosphamide", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:3002", "code": "3002", "name": "cyclophosphamide", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3002" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1310317", "code": "1310317", "name": "cyclophosphamide", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1310317" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:387420009", "code": "387420009", "name": "Cyclophosphamide", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=387420009&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4299054", "code": "4299054", "name": "Cyclophosphamide", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4299054" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "Alkylating chemotherapy" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Chemotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C405", "code": "C405", "name": "Cyclophosphamide", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C405" ] } }, { "id": "tx:ncit:C62028", "conceptType": "Therapy", "name": "Epirubicin", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:3995", "code": "3995", "name": "epirubicin", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3995" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1344354", "code": "1344354", "name": "epirubicin", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1344354" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:417916005", "code": "417916005", "name": "Epirubicin", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=417916005&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4166710", "code": "4166710", "name": "Epirubicin", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4166710" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "Topoisomerase inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Chemotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C62028", "code": "C62028", "name": "Epirubicin", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62028" ] } }, { "id": "tx:ncit:C1411", "conceptType": "Therapy", "name": "Paclitaxel", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:56946", "code": "56946", "name": "paclitaxel", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=56946" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4306859", "code": "4306859", "name": "Paclitaxel", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4306859" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:387374002", "code": "387374002", "name": "Paclitaxel", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=387374002&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1378382", "code": "1378382", "name": "paclitaxel", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1378382" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "Taxane-based chemotherapy" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Chemotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C1411", "code": "C1411", "name": "Paclitaxel", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1411" ] } }, { "id": "tx:ncit:C38692", "conceptType": "Therapy", "name": "Pertuzumab", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:1298944", "code": "1298944", "name": "pertuzumab", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1298944" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:42801287", "code": "42801287", "name": "pertuzumab", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/42801287" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:704226002", "code": "704226002", "name": "Pertuzumab", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=704226002&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:45766952", "code": "45766952", "name": "Pertuzumab", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/45766952" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "HER2 inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C38692", "code": "C38692", "name": "Pertuzumab", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C38692" ] } }, { "id": "tx:ncit:C1647", "conceptType": "Therapy", "name": "Trastuzumab", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:224905", "code": "224905", "name": "trastuzumab", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=224905" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4304158", "code": "4304158", "name": "Trastuzumab", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4304158" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:387003001", "code": "387003001", "name": "Trastuzumab", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=387003001&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1387104", "code": "1387104", "name": "trastuzumab", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1387104" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "HER2 inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C1647", "code": "C1647", "name": "Trastuzumab", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1647" ] } } ] }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:20", "present": true, "subject": { "id": "bmkr:20", "type": "CategoricalVariant", "name": "HER2-positive", "constraints": [], "extensions": [ { "name": "biomarker_type", "value": "Protein expression" }, { "name": "marker", "value": "Human epidermal growth factor receptor 2 (HER2)" }, { "name": "unit", "value": "status" }, { "name": "equality", "value": "=" }, { "name": "value", "value": "Positive" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }