{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:363 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A363", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001763, "timestamp_received": "2026-09-25T01:15:54.136249+00:00Z", "timestamp_returned": "2026-09-25T01:15:54.138012+00:00Z", "trace_id": "a9724140-d2b8-40a4-a331-a9f0e1ef1af7" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:363", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:CML", "conceptType": "Disease", "name": "Chronic Myelogenous Leukemia", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": false, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:CML", "code": "CML", "name": "Chronic Myelogenous Leukemia", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=CML" ] } }, "objectTherapeutic": { "id": "tx:ncit:C95777", "conceptType": "Therapy", "name": "Ponatinib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:1364347", "code": "1364347", "name": "ponatinib", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1364347" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:45771379", "code": "45771379", "name": "Ponatinib", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/45771379" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:703796003", "code": "703796003", "name": "Ponatinib", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=703796003&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:43013182", "code": "43013182", "name": "ponatinib", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/43013182" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "BCR-ABL inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C95777", "code": "C95777", "name": "Ponatinib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C95777" ] } }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:32", "present": true, "subject": { "id": "bmkr:32", "type": "CategoricalVariant", "name": "ABL1 p.T315I", "constraints": [ { "type": "DefiningAlleleConstraint", "allele": { "id": "ga4gh:VA.D6NzpWXKqBnbcZZrXNSXj4tMUwROKbsQ", "type": "Allele", "name": "NP_005148.2:p.Thr315Ile", "aliases": [ "NP_005148.2:p.T315I", "ABL1 p.T315I" ], "description": "VRS variation of NP_005148.2:p.Thr315Ile", "digest": "D6NzpWXKqBnbcZZrXNSXj4tMUwROKbsQ", "expressions": [ { "syntax": "hgvs.p", "value": "NP_005148.2:p.Thr315Ile", "extensions": [ { "name": "hgvs.p_short", "value": "p.T315I" } ] } ], "location": { "id": "ga4gh:SL.jGElwyBPYNWI-BkFFHKfgLJynt9zuNPs", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Amino acid position 315 of the Refseq protein NP_005148.2, which is the protein product of the MANE Select coding transcript for ABL1 (refseq:NM_005157.6).", "digest": "jGElwyBPYNWI-BkFFHKfgLJynt9zuNPs", "sequenceReference": { "id": "ga4gh:SQ.dmFigTG-0fY6I54swb7PoDuxCeT6O3Wg", "type": "SequenceReference", "name": "NP_005148.2", "aliases": [ "ensembl:ENSP00000323315.5", "ga4gh:SQ.dmFigTG-0fY6I54swb7PoDuxCeT6O3Wg", "refseq:NP_005148.2" ], "description": "The protein product of the MANE Select coding transcript for ABL1 (refseq:NM_005157.6), corresponding to the Refseq protein accession NP_005148.2.", "moleculeType": "protein", "refgetAccession": "SQ.dmFigTG-0fY6I54swb7PoDuxCeT6O3Wg", "residueAlphabet": "aa" }, "start": 314, "end": 315, "sequence": "T" }, "state": { "type": "LiteralSequenceExpression", "sequence": "I" } }, "relations": [] }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:76", "conceptType": "Gene", "name": "ABL1", "primaryCoding": { "id": "coding:hgnc:76", "code": "HGNC:76", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:76" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000097007", "code": "ENSG00000097007", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000097007" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:25", "code": "25", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/25" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_005157.6", "code": "NM_005157.6", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_005157.6" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "9" }, { "name": "start_position", "value": 133748283 }, { "name": "end_position", "value": 133748283 }, { "name": "reference_allele", "value": "C" }, { "name": "alternate_allele", "value": "T" }, { "name": "cdna_change", "value": "c.944C>T" }, { "name": "protein_change", "value": "p.T315I" }, { "name": "variant_annotation", "value": "Missense" }, { "name": "exon", "value": 5 }, { "name": "rsid", "value": "rs121913459" }, { "name": "hgvsg", "value": "9:g.133748283C>T" }, { "name": "hgvsc", "value": "ENST00000318560.5:c.944C>T" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }