{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:367 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A367", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001869, "timestamp_received": "2026-09-25T00:12:11.239645+00:00Z", "timestamp_returned": "2026-09-25T00:12:11.241514+00:00Z", "trace_id": "14fe6e9e-fcf0-46ec-9f3e-c5721723423d" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:367", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:NSCLC", "conceptType": "Disease", "name": "Non-Small Cell Lung Cancer", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:NSCLC", "code": "NSCLC", "name": "Non-Small Cell Lung Cancer", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=NSCLC" ] } }, "objectTherapeutic": { "id": "txgrp:76", "membershipOperator": "AND", "therapies": [ { "id": "tx:ncit:C65530", "conceptType": "Therapy", "name": "Erlotinib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:337525", "code": "337525", "name": "erlotinib", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=337525" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4185613", "code": "4185613", "name": "Erlotinib", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4185613" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:414123001", "code": "414123001", "name": "Erlotinib", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=414123001&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1325363", "code": "1325363", "name": "erlotinib", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1325363" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "EGFR inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C65530", "code": "C65530", "name": "Erlotinib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C65530" ] } }, { "id": "tx:ncit:C70792", "conceptType": "Therapy", "name": "Ramucirumab", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:1535922", "code": "1535922", "name": "ramucirumab", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1535922" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:45766980", "code": "45766980", "name": "Ramucirumab", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/45766980" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:704259004", "code": "704259004", "name": "Ramucirumab", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=704259004&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:44818489", "code": "44818489", "name": "ramucirumab", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/44818489" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "VEGF/VEGFR inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C70792", "code": "C70792", "name": "Ramucirumab", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70792" ] } } ] }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:9", "present": true, "subject": { "id": "bmkr:9", "type": "CategoricalVariant", "name": "EGFR p.L858R", "constraints": [ { "type": "DefiningAlleleConstraint", "allele": { "id": "ga4gh:VA.S41CcMJT2bcd8R4-qXZWH1PoHWNtG2PZ", "type": "Allele", "name": "NP_005219.2:p.Leu858Arg", "aliases": [ "NP_005219.2:p.L858R", "EGFR p.L858R" ], "description": "VRS variation of NP_005219.2:p.Leu858Arg", "digest": "S41CcMJT2bcd8R4-qXZWH1PoHWNtG2PZ", "expressions": [ { "syntax": "hgvs.p", "value": "NP_005219.2:p.Leu858Arg", "extensions": [ { "name": "hgvs.p_short", "value": "p.L858R" } ] } ], "location": { "id": "ga4gh:SL.v0_edynH98OIu-0QPVT5anCSOriAFSDQ", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Amino acid position 858 of the Refseq protein NP_005219.2, which is the protein product of the MANE Select coding transcript for EGFR (refseq:NM_005228.5).", "digest": "v0_edynH98OIu-0QPVT5anCSOriAFSDQ", "sequenceReference": { "id": "ga4gh:SQ.vyo55F6mA6n2LgN4cagcdRzOuh38V4mE", "type": "SequenceReference", "name": "NP_005219.2", "aliases": [ "ensembl:ENSP00000275493.2", "ga4gh:SQ.vyo55F6mA6n2LgN4cagcdRzOuh38V4mE", "refseq:NP_005219.2" ], "description": "The protein product of the MANE Select coding transcript for EGFR (refseq:NM_005228.5), corresponding to the Refseq protein accession NP_005219.2.", "moleculeType": "protein", "refgetAccession": "SQ.vyo55F6mA6n2LgN4cagcdRzOuh38V4mE", "residueAlphabet": "aa" }, "start": 857, "end": 858, "sequence": "L" }, "state": { "type": "LiteralSequenceExpression", "sequence": "R" } }, "relations": [] }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:3236", "conceptType": "Gene", "name": "EGFR", "primaryCoding": { "id": "coding:hgnc:3236", "code": "HGNC:3236", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3236" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000146648", "code": "ENSG00000146648", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000146648" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:1956", "code": "1956", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/1956" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_005228.5", "code": "NM_005228.5", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_005228.5" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "7" }, { "name": "start_position", "value": 55259515 }, { "name": "end_position", "value": 55259515 }, { "name": "reference_allele", "value": "T" }, { "name": "alternate_allele", "value": "G" }, { "name": "cdna_change", "value": "c.2573T>G" }, { "name": "protein_change", "value": "p.L858R" }, { "name": "variant_annotation", "value": "Missense" }, { "name": "exon", "value": 21 }, { "name": "rsid", "value": "rs121434568" }, { "name": "hgvsg", "value": "7:g.55259515T>G" }, { "name": "hgvsc", "value": "ENST00000275493.2:c.2573T>G" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }