{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:377 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A377",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001838,
    "timestamp_received": "2026-09-25T01:15:46.563975+00:00Z",
    "timestamp_returned": "2026-09-25T01:15:46.565813+00:00Z",
    "trace_id": "11226893-5111-4d4d-9a44-a1136a7c7955"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:377",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:BRCA",
        "conceptType": "Disease",
        "name": "Invasive Breast Carcinoma",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:oncotree:BRCA",
          "code": "BRCA",
          "name": "Invasive Breast Carcinoma",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=BRCA"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "txgrp:78",
        "membershipOperator": "AND",
        "therapies": [
          {
            "id": "tx:ncit:C1527",
            "conceptType": "Therapy",
            "name": "Letrozole",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:72965",
                  "code": "72965",
                  "name": "letrozole",
                  "system": "RxNorm",
                  "systemVersion": "20250602",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=72965"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:4297547",
                  "code": "4297547",
                  "name": "Letrozole",
                  "system": "OMOP",
                  "systemVersion": "v20250827",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/4297547"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:386911004",
                  "code": "386911004",
                  "name": "Letrozole",
                  "system": "SNOMED",
                  "systemVersion": "2026-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=386911004&edition=MAIN/2026-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:1315946",
                  "code": "1315946",
                  "name": "letrozole",
                  "system": "OMOP",
                  "systemVersion": "v20250827",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/1315946"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Aromatase inhibition"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Hormone therapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C1527",
              "code": "C1527",
              "name": "Letrozole",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1527"
              ]
            }
          },
          {
            "id": "tx:ncit:C95701",
            "conceptType": "Therapy",
            "name": "Ribociclib",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:1873916",
                  "code": "1873916",
                  "name": "ribociclib",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1873916"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:1592911",
                  "code": "1592911",
                  "name": "ribociclib",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/1592911"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:732257004",
                  "code": "732257004",
                  "name": "Ribociclib",
                  "system": "SNOMED",
                  "systemVersion": "2025-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=732257004&edition=MAIN/2025-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:37115766",
                  "code": "37115766",
                  "name": "Ribociclib",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/37115766"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "CDK4/6 inhibition"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Targeted therapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C95701",
              "code": "C95701",
              "name": "Ribociclib",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C95701"
              ]
            }
          }
        ]
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:1",
              "present": true,
              "subject": {
                "id": "bmkr:1",
                "type": "CategoricalVariant",
                "name": "ER positive",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "Estrogen receptor (ER)"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Positive"
                  }
                ]
              }
            },
            {
              "id": "bmkr.criterion:2",
              "present": true,
              "subject": {
                "id": "bmkr:2",
                "type": "CategoricalVariant",
                "name": "HER2-negative",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "Human epidermal growth factor receptor 2 (HER2)"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Negative"
                  }
                ]
              }
            },
            {
              "id": "bmkr.criterion:3",
              "present": true,
              "subject": {
                "id": "bmkr:3",
                "type": "CategoricalVariant",
                "name": "PR positive",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "Progesterone receptor (PR)"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Positive"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}