{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:384 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A384", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001951, "timestamp_received": "2026-09-25T00:12:24.541445+00:00Z", "timestamp_returned": "2026-09-25T00:12:24.543396+00:00Z", "trace_id": "07d2f7d7-11d6-43e2-a586-917231943213" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:384", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:BL", "conceptType": "Disease", "name": "Burkitt Lymphoma", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": false, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:BL", "code": "BL", "name": "Burkitt Lymphoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=BL" ] } }, "objectTherapeutic": { "id": "txgrp:82", "membershipOperator": "AND", "therapies": [ { "id": "tx:ncit:C405", "conceptType": "Therapy", "name": "Cyclophosphamide", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:3002", "code": "3002", "name": "cyclophosphamide", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3002" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1310317", "code": "1310317", "name": "cyclophosphamide", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1310317" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:387420009", "code": "387420009", "name": "Cyclophosphamide", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=387420009&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4299054", "code": "4299054", "name": "Cyclophosphamide", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4299054" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "Alkylating chemotherapy" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Chemotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C405", "code": "C405", "name": "Cyclophosphamide", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C405" ] } }, { "id": "tx:ncit:C456", "conceptType": "Therapy", "name": "Doxorubicin", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:3639", "code": "3639", "name": "doxorubicin", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3639" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4187583", "code": "4187583", "name": "Doxorubicin", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4187583" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:372817009", "code": "372817009", "name": "Doxorubicin", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=372817009&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1338512", "code": "1338512", "name": "doxorubicin", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1338512" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "Topoisomerase inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Chemotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C456", "code": "C456", "name": "Doxorubicin", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C456" ] } }, { "id": "tx:ncit:C1702", "conceptType": "Therapy", "name": "Rituximab", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:121191", "code": "121191", "name": "rituximab", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=121191" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1314273", "code": "1314273", "name": "rituximab", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1314273" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:386919002", "code": "386919002", "name": "Rituximab", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=386919002&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4299850", "code": "4299850", "name": "Rituximab", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4299850" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "CD20 inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Immunotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C1702", "code": "C1702", "name": "Rituximab", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1702" ] } }, { "id": "tx:ncit:C770", "conceptType": "Therapy", "name": "Prednisone", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:8640", "code": "8640", "name": "prednisone", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8640" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1551099", "code": "1551099", "name": "prednisone", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1551099" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:116602009", "code": "116602009", "name": "Prednisone", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=116602009&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4023242", "code": "4023242", "name": "Prednisone", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4023242" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "Corticosteroid" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Chemotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C770", "code": "C770", "name": "Prednisone", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C770" ] } }, { "id": "tx:ncit:C933", "conceptType": "Therapy", "name": "Vincristine", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:11202", "code": "11202", "name": "vincristine", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=11202" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1308290", "code": "1308290", "name": "vincristine", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1308290" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:387126006", "code": "387126006", "name": "Vincristine", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=387126006&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4304296", "code": "4304296", "name": "Vincristine", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4304296" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "Vinca alkaloid chemotherapy" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Chemotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C933", "code": "C933", "name": "Vincristine", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C933" ] } } ] }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:54", "present": true, "subject": { "id": "bmkr:54", "type": "CategoricalVariant", "name": "CD20 +", "constraints": [], "extensions": [ { "name": "biomarker_type", "value": "Protein expression" }, { "name": "marker", "value": "CD20" }, { "name": "unit", "value": "status" }, { "name": "equality", "value": "=" }, { "name": "value", "value": "Positive" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }