{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:39 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A39", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001855, "timestamp_received": "2026-09-25T00:12:14.084899+00:00Z", "timestamp_returned": "2026-09-25T00:12:14.086754+00:00Z", "trace_id": "a77470d0-6d06-4423-a460-828eaa6e236a" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:39", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:MEL", "conceptType": "Disease", "name": "Melanoma", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:MEL", "code": "MEL", "name": "Melanoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=MEL" ] } }, "objectTherapeutic": { "id": "txgrp:9", "membershipOperator": "AND", "therapies": [ { "id": "tx:ncit:C106250", "conceptType": "Therapy", "name": "Atezolizumab", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:1792776", "code": "1792776", "name": "atezolizumab", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ 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"C68923", "name": "Cobimetinib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C68923" ] } }, { "id": "tx:ncit:C64768", "conceptType": "Therapy", "name": "Vemurafenib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:1147220", "code": "1147220", "name": "vemurafenib", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1147220" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:45765787", "code": "45765787", "name": "Vemurafenib", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/45765787" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:702805007", "code": "702805007", "name": "Vemurafenib", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=702805007&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:40241937", "code": "40241937", "name": "vemurafenib", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/40241937" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "B-RAF inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C64768", "code": "C64768", "name": "Vemurafenib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C64768" ] } } ] }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:17", "present": true, "subject": { "id": "bmkr:17", "type": "CategoricalVariant", "name": "BRAF p.V600K", "constraints": [ { "type": "DefiningAlleleConstraint", "allele": { "id": "ga4gh:VA.pfWn9x9oFBRzGda1xXcOrE-BrX0R__N8", "type": "Allele", "name": "NP_004324.2:p.Val600Lys", "aliases": [ "NP_004324.2:p.V600K", "BRAF p.V600K" ], "description": "VRS variation of NP_004324.2:p.Val600Lys", "digest": "pfWn9x9oFBRzGda1xXcOrE-BrX0R__N8", "expressions": [ { "syntax": "hgvs.p", "value": "NP_004324.2:p.Val600Lys", "extensions": [ { "name": "hgvs.p_short", "value": "p.V600K" } ] } ], "location": { "id": "ga4gh:SL.t-3DrWALhgLdXHsupI-e-M00aL3HgK3y", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Amino acid position 600 of the Refseq protein NP_004324.2, which is the protein product of the MANE Select coding transcript for BRAF (refseq:NM_004333.6).", "digest": "t-3DrWALhgLdXHsupI-e-M00aL3HgK3y", "sequenceReference": { "id": "ga4gh:SQ.cQvw4UsHHRRlogxbWCB8W-mKD4AraM9y", "type": "SequenceReference", "name": "NP_004324.2", "aliases": [ "ensembl:ENSP00000288602.6", "ga4gh:SQ.cQvw4UsHHRRlogxbWCB8W-mKD4AraM9y", "refseq:NP_004324.2" ], "description": "The protein product of the MANE Select coding transcript for BRAF (refseq:NM_004333.6), corresponding to the Refseq protein accession NP_004324.2.", "moleculeType": "protein", "refgetAccession": "SQ.cQvw4UsHHRRlogxbWCB8W-mKD4AraM9y", "residueAlphabet": "aa" }, "start": 599, "end": 600, "sequence": "V" }, "state": { "type": "LiteralSequenceExpression", "sequence": "K" } }, "relations": [] }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:1097", "conceptType": "Gene", "name": "BRAF", "primaryCoding": { "id": "coding:hgnc:1097", "code": "HGNC:1097", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1097" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000157764", "code": "ENSG00000157764", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000157764" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:673", "code": "673", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/673" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_004333.6", "code": "NM_004333.6", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_004333.6" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "7" }, { "name": "start_position", "value": 140453136 }, { "name": "end_position", "value": 140453137 }, { "name": "reference_allele", "value": "AC" }, { "name": "alternate_allele", "value": "TT" }, { "name": "cdna_change", "value": "c.1798_1799GT>AA" }, { "name": "protein_change", "value": "p.V600K" }, { "name": 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Multiple biomarkers are combined with implied AND logic." } ] } ] }