{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:413 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A413", "status": "success", "status_code": 200, "timestamp_elapsed": 0.0029, "timestamp_received": "2026-09-25T00:12:15.726890+00:00Z", "timestamp_returned": "2026-09-25T00:12:15.729790+00:00Z", "trace_id": "12c037e9-c114-4793-bc4f-3c7d8ee27541" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:413", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:BRCA", "conceptType": "Disease", "name": "Invasive Breast Carcinoma", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:BRCA", "code": "BRCA", "name": "Invasive Breast Carcinoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=BRCA" ] } }, "objectTherapeutic": { "id": "tx:ncit:C95733", "conceptType": "Therapy", "name": "Talazoparib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2099704", "code": "2099704", "name": "talazoparib", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2099704" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:35201068", "code": "35201068", "name": "talazoparib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/35201068" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:782199007", "code": "782199007", "name": "Talazoparib", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=782199007&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:36684109", "code": "36684109", "name": "Talazoparib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/36684109" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "PARP inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C95733", "code": "C95733", "name": "Talazoparib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C95733" ] } }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:50", "present": true, "subject": { "id": "bmkr:50", "type": "CategoricalVariant", "name": "BRCA2 pathogenic variants", "constraints": [ { "type": "DefiningLocationConstraint", "location": { "id": "ga4gh:SL.7RukGUDX8Q-lC8U7OIIL3hRCBfXr7tji", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Sequence spanning the length of refseq:NP_000050.3, the protein product of the MANE Select coding transcript for BRCA2 (refseq:NM_000059.4).", "digest": "7RukGUDX8Q-lC8U7OIIL3hRCBfXr7tji", "sequenceReference": { "id": "ga4gh:SQ.A6rzuv6kdsuIp6gy6fykzgzyJe9NJOC9", "type": "SequenceReference", "name": "NP_000050.3", "aliases": [ "ensembl:ENSP00000369497.3", "ga4gh:SQ.A6rzuv6kdsuIp6gy6fykzgzyJe9NJOC9", "refseq:NP_000050.3" ], "description": "The protein product of the MANE Select coding transcript for BRCA2 (refseq:NM_000059.4), corresponding to the Refseq protein accession NP_000050.3.", "moleculeType": "protein", "refgetAccession": "SQ.A6rzuv6kdsuIp6gy6fykzgzyJe9NJOC9", "residueAlphabet": "aa" }, "start": 0, "end": 3418, "sequence": null }, "relations": [], "matchCharacteristic": { "primaryCoding": { "code": "is_within", "system": "ga4gh-gks-term:location-match" } } }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:1101", "conceptType": "Gene", "name": "BRCA2", "primaryCoding": { "id": "coding:hgnc:1101", "code": "HGNC:1101", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1101" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000139618", "code": "ENSG00000139618", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000139618" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:675", "code": "675", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/675" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_000059.4", "code": "NM_000059.4", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_000059.4" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Germline variant" }, { "name": "chromosome", "value": "13" }, { "name": "start_position", "value": null }, { "name": "end_position", "value": null }, { "name": "reference_allele", "value": null }, { "name": "alternate_allele", "value": null }, { "name": "cdna_change", "value": null }, { "name": "protein_change", "value": null }, { "name": "variant_annotation", "value": null }, { "name": "exon", "value": null }, { "name": "rsid", "value": null }, { "name": "hgvsg", "value": null }, { "name": "hgvsc", "value": null }, { "name": "requires_pathogenic", "value": true } ] } }, { "id": "bmkr.criterion:2", "present": true, "subject": { "id": "bmkr:2", "type": "CategoricalVariant", "name": "HER2-negative", "constraints": [], "extensions": [ { "name": "biomarker_type", "value": "Protein expression" }, { "name": "marker", "value": "Human epidermal growth factor receptor 2 (HER2)" }, { "name": "unit", "value": "status" }, { "name": "equality", "value": "=" }, { "name": "value", "value": "Negative" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }