{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:422 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A422", "status": "success", "status_code": 200, "timestamp_elapsed": 0.00194, "timestamp_received": "2026-09-25T00:12:35.158259+00:00Z", "timestamp_returned": "2026-09-25T00:12:35.160199+00:00Z", "trace_id": "de5ddd4e-9bc4-4fcf-8a1d-1c9a6d198a4f" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:422", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:NSCLC", "conceptType": "Disease", "name": "Non-Small Cell Lung Cancer", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:NSCLC", "code": "NSCLC", "name": "Non-Small Cell Lung Cancer", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=NSCLC" ] } }, "objectTherapeutic": { "id": "tx:ncit:C128799", "conceptType": "Therapy", "name": "Trastuzumab deruxtecan", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2267582", "code": "2267582", "name": "trastuzumab deruxtecan", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2267582" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:3666979", "code": "3666979", "name": "Trastuzumab deruxtecan", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/3666979" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:838469001", "code": "838469001", "name": "Trastuzumab deruxtecan", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=838469001&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:37498192", "code": "37498192", "name": "trastuzumab deruxtecan", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/37498192" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "HER2 inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C128799", "code": "C128799", "name": "Trastuzumab Deruxtecan", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C128799" ] } }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:23", "present": true, "subject": { "id": "bmkr:23", "type": "CategoricalVariant", "name": "ERBB2 activating variants", "constraints": [ { "type": "DefiningLocationConstraint", "location": { "id": "ga4gh:SL.tZDv33gDtUO9Ow5G83xXdvKSwKVkBPkq", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Sequence spanning the length of refseq:NP_004439.2, the protein product of the MANE Select coding transcript for ERBB2 (refseq:NM_004448.4).", "digest": "tZDv33gDtUO9Ow5G83xXdvKSwKVkBPkq", "sequenceReference": { "id": "ga4gh:SQ.AF1UFydIo02-bMplonKSfxlWY2q6ze3m", "type": "SequenceReference", "name": "NP_004439.2", "aliases": [ "ensembl:ENSP00000269571.4", "ga4gh:SQ.AF1UFydIo02-bMplonKSfxlWY2q6ze3m", "refseq:NP_004439.2" ], "description": "The protein product of the MANE Select coding transcript for ERBB2 (refseq:NM_004448.4), corresponding to the Refseq protein accession NP_004439.2.", "moleculeType": "protein", "refgetAccession": "SQ.AF1UFydIo02-bMplonKSfxlWY2q6ze3m", "residueAlphabet": "aa" }, "start": 0, "end": 1255, "sequence": null }, "relations": [], "matchCharacteristic": { "primaryCoding": { "code": "is_within", "system": "ga4gh-gks-term:location-match" } } }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:3430", "conceptType": "Gene", "name": "ERBB2", "primaryCoding": { "id": "coding:hgnc:3430", "code": "HGNC:3430", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3430" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000141736", "code": "ENSG00000141736", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000141736" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:2064", "code": "2064", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/2064" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_004448.4", "code": "NM_004448.4", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_004448.4" ] } } ] } }, { "type": "FunctionConstraint", "functionConsequence": { "id": "func:so:0002053", "name": "Gain-of-function", "primaryCoding": { "id": "coding:so:0002053", "code": "SO:0002053", "name": "gain_of_function_variant", "system": "https://www.ebi.ac.uk/ols4/ontologies/so", "iris": [ "https://www.ebi.ac.uk/ols4/ontologies/so/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FSO_0002053" ] } } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "17" }, { "name": "start_position", "value": null }, { "name": "end_position", "value": null }, { "name": "reference_allele", "value": null }, { "name": "alternate_allele", "value": null }, { "name": "cdna_change", "value": null }, { "name": "protein_change", "value": null }, { "name": "variant_annotation", "value": null }, { "name": "exon", "value": null }, { "name": "rsid", "value": null }, { "name": "hgvsg", "value": null }, { "name": "hgvsc", "value": null }, { "name": "requires_oncogenic", "value": true } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }