{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:435 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A435", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001816, "timestamp_received": "2026-09-25T01:14:56.585534+00:00Z", "timestamp_returned": "2026-09-25T01:14:56.587350+00:00Z", "trace_id": "9cfe5111-c4f6-4244-9002-1af561fbfac9" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:435", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:FL", "conceptType": "Disease", "name": "Follicular Lymphoma", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": false, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:FL", "code": "FL", "name": "Follicular Lymphoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=FL" ] } }, "objectTherapeutic": { "id": "tx:ncit:C107506", "conceptType": "Therapy", "name": "Tazemetostat", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2274378", "code": "2274378", "name": "tazemetostat", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2274378" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:37498602", "code": "37498602", "name": "tazemetostat", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/37498602" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:840405005", "code": "840405005", "name": "Tazemetostat", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=840405005&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:3666985", "code": "3666985", "name": "Tazemetostat", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/3666985" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "EZH2 inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C107506", "code": "C107506", "name": "Tazemetostat", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C107506" ] } }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:151", "present": true, "subject": { "id": "bmkr:151", "type": "CategoricalVariant", "name": "EZH2 p.A692V", "constraints": [ { "type": "DefiningAlleleConstraint", "allele": { "id": "ga4gh:VA.Asy9WpmrMOSunO4H7D3OU7t4MvIbBWK9", "type": "Allele", "name": "NP_004447.2:p.Ala692Val", "aliases": [ "NP_004447.2:p.A692V", "EZH2 p.A692V" ], "description": "VRS variation of NP_004447.2:p.Ala692Val", "digest": "Asy9WpmrMOSunO4H7D3OU7t4MvIbBWK9", "expressions": [ { "syntax": "hgvs.p", "value": "NP_004447.2:p.Ala692Val", "extensions": [ { "name": "hgvs.p_short", "value": "p.A692V" } ] } ], "location": { "id": "ga4gh:SL.zgMYyYar7JOGCMcyd4F4CKRQMoBqM7qY", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Amino acid position 692 of the Refseq protein NP_004447.2, which is the protein product of the MANE Select coding transcript for EZH2 (refseq:NM_004456.5).", "digest": "zgMYyYar7JOGCMcyd4F4CKRQMoBqM7qY", "sequenceReference": { "id": "ga4gh:SQ.fZuyp1_QKM5vGWsn-O-CrPHPm5jR403J", "type": "SequenceReference", "name": "NP_004447.2", "aliases": [ "ensembl:ENSP00000320147.2", "ga4gh:SQ.fZuyp1_QKM5vGWsn-O-CrPHPm5jR403J", "refseq:NP_004447.2" ], "description": "The protein product of the MANE Select coding transcript for EZH2 (refseq:NM_004456.5), corresponding to the Refseq protein accession NP_004447.2.", "moleculeType": "protein", "refgetAccession": "SQ.fZuyp1_QKM5vGWsn-O-CrPHPm5jR403J", "residueAlphabet": "aa" }, "start": 691, "end": 692, "sequence": "A" }, "state": { "type": "LiteralSequenceExpression", "sequence": "V" } }, "relations": [] }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:3527", "conceptType": "Gene", "name": "EZH2", "primaryCoding": { "id": "coding:hgnc:3527", "code": "HGNC:3527", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3527" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000106462", "code": "ENSG00000106462", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000106462" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:2146", "code": "2146", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/2146" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_004456.5", "code": "NM_004456.5", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_004456.5" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "7" }, { "name": "start_position", "value": 148506437 }, { "name": "end_position", "value": 148506437 }, { "name": "reference_allele", "value": "G" }, { "name": "alternate_allele", "value": "A" }, { "name": "cdna_change", "value": "c.2075C>T" }, { "name": "protein_change", "value": "p.A692V" }, { "name": "variant_annotation", "value": "Missense" }, { "name": "exon", "value": "18/20" }, { "name": "rsid", "value": "rs2129467667" }, { "name": "hgvsg", "value": "7:g.148506437G>A" }, { "name": "hgvsc", "value": "ENST00000320356.2:c.2075C>T" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }