{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:456 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A456",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001812,
    "timestamp_received": "2026-09-25T00:12:46.048037+00:00Z",
    "timestamp_returned": "2026-09-25T00:12:46.049849+00:00Z",
    "trace_id": "26b74884-ddbb-496e-922f-d45f3fa2dc07"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
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      "id": "prop:vtxr:456",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:PRAD",
        "conceptType": "Disease",
        "name": "Prostate Adenocarcinoma",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
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          "name": "Prostate Adenocarcinoma",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=PRAD"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "txgrp:44",
        "membershipOperator": "AND",
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            "id": "tx:ncit:C71744",
            "conceptType": "Therapy",
            "name": "Enzalutamide",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
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                  "code": "1307298",
                  "name": "enzalutamide",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1307298"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:42900250",
                  "code": "42900250",
                  "name": "enzalutamide",
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                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/42900250"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:703125003",
                  "code": "703125003",
                  "name": "Enzalutamide",
                  "system": "SNOMED",
                  "systemVersion": "2025-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=703125003&edition=MAIN/2025-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:45773162",
                  "code": "45773162",
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                  "iris": [
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                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Antiandrogen"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Hormone therapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C71744",
              "code": "C71744",
              "name": "Enzalutamide",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C71744"
              ]
            }
          },
          {
            "id": "tx:ncit:C95733",
            "conceptType": "Therapy",
            "name": "Talazoparib",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
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                  "code": "2099704",
                  "name": "talazoparib",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
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                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:35201068",
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                  "name": "talazoparib",
                  "system": "OMOP",
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                  "iris": [
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                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:782199007",
                  "code": "782199007",
                  "name": "Talazoparib",
                  "system": "SNOMED",
                  "systemVersion": "2025-03-01",
                  "iris": [
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                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
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                  "code": "36684109",
                  "name": "Talazoparib",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/36684109"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
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                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Targeted therapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C95733",
              "code": "C95733",
              "name": "Talazoparib",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C95733"
              ]
            }
          }
        ]
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:168",
              "present": true,
              "subject": {
                "id": "bmkr:168",
                "type": "CategoricalVariant",
                "name": "NBN oncogenic variants",
                "constraints": [
                  {
                    "type": "DefiningLocationConstraint",
                    "location": {
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                      "name": null,
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                        "moleculeType": "protein",
                        "refgetAccession": "SQ.T4LwZqLKWSYumPA4OW8G35Q3I81OGuma",
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                        "system": "ga4gh-gks-term:location-match"
                      }
                    }
                  },
                  {
                    "type": "FeatureContextConstraint",
                    "featureContext": {
                      "id": "gene:hgnc:7652",
                      "conceptType": "Gene",
                      "name": "NBN",
                      "primaryCoding": {
                        "id": "coding:hgnc:7652",
                        "code": "HGNC:7652",
                        "system": "https://genenames.org",
                        "iris": [
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                        ]
                      },
                      "mappings": [
                        {
                          "relation": "exactMatch",
                          "coding": {
                            "id": "coding:ensembl:ensg00000104320",
                            "code": "ENSG00000104320",
                            "system": "https://www.ensembl.org",
                            "iris": [
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                          }
                        },
                        {
                          "relation": "exactMatch",
                          "coding": {
                            "id": "coding:ncbi:4683",
                            "code": "4683",
                            "system": "https://www.ncbi.nlm.nih.gov/gene",
                            "iris": [
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                        },
                        {
                          "relation": "relatedMatch",
                          "coding": {
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                            "code": "NM_057091.3",
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                            "iris": [
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                          }
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                      ]
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                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Somatic variant"
                  },
                  {
                    "name": "chromosome",
                    "value": "8"
                  },
                  {
                    "name": "start_position",
                    "value": null
                  },
                  {
                    "name": "end_position",
                    "value": null
                  },
                  {
                    "name": "reference_allele",
                    "value": null
                  },
                  {
                    "name": "alternate_allele",
                    "value": null
                  },
                  {
                    "name": "cdna_change",
                    "value": null
                  },
                  {
                    "name": "protein_change",
                    "value": null
                  },
                  {
                    "name": "variant_annotation",
                    "value": null
                  },
                  {
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                    "value": null
                  },
                  {
                    "name": "rsid",
                    "value": null
                  },
                  {
                    "name": "hgvsg",
                    "value": null
                  },
                  {
                    "name": "hgvsc",
                    "value": null
                  },
                  {
                    "name": "requires_oncogenic",
                    "value": true
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                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}