{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:461 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A461",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.00183,
    "timestamp_received": "2026-09-25T00:11:57.951543+00:00Z",
    "timestamp_returned": "2026-09-25T00:11:57.953373+00:00Z",
    "trace_id": "8b158454-8022-4d8e-bcfb-3d79419935a2"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
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      "id": "prop:vtxr:461",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:ncit:C3696",
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        "name": "Subependymal Giant Cell Astrocytoma",
        "mappings": [
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            "relation": "broadMatch",
            "coding": {
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              "code": "ENCG",
              "name": "Encapsulated Glioma",
              "system": "https://oncotree.mskcc.org",
              "systemVersion": "oncotree_2025_10_03",
              "iris": [
                "https://oncotree.mskcc.org/?version=oncotree_2025_10_03&field=NAME&search=Encapsulated+Glioma+%28ENCG%29"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
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          "id": "coding:ncit:C3696",
          "code": "C3696",
          "name": "Subependymal Giant Cell Astrocytoma",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3696"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C48387",
        "conceptType": "Therapy",
        "name": "Everolimus",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:141704",
              "code": "141704",
              "name": "everolimus",
              "system": "RxNorm",
              "systemVersion": "20250602",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=141704"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:4324761",
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              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/4324761"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:sctid:428698007",
              "code": "428698007",
              "name": "Everolimus",
              "system": "SNOMED",
              "systemVersion": "2026-03-01",
              "iris": [
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              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:19011440",
              "code": "19011440",
              "name": "everolimus",
              "system": "OMOP",
              "systemVersion": "v20250827",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/19011440"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "PI3K/AKT/mTOR inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C48387",
          "code": "C48387",
          "name": "Everolimus",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C48387"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:159",
              "present": true,
              "subject": {
                "id": "bmkr:159",
                "type": "CategoricalVariant",
                "name": "TSC2 oncogenic variants",
                "constraints": [
                  {
                    "type": "DefiningLocationConstraint",
                    "location": {
                      "id": "ga4gh:SL.s7vO8-3vGOCLvGBe_ew5CW-pCuKGx-_S",
                      "type": "SequenceLocation",
                      "name": null,
                      "aliases": [],
                      "description": "Sequence spanning the length of refseq:NP_000539.2, the protein product of the MANE Select coding transcript for TSC2 (refseq:NM_000548.5).",
                      "digest": "s7vO8-3vGOCLvGBe_ew5CW-pCuKGx-_S",
                      "sequenceReference": {
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                        "type": "SequenceReference",
                        "name": "NP_000539.2",
                        "aliases": [
                          "ensembl:ENSP00000219476.3",
                          "ga4gh:SQ.OBQRUmiVewAVPYXV5ACyxczHF1Q4YGOm",
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                        ],
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                        "moleculeType": "protein",
                        "refgetAccession": "SQ.OBQRUmiVewAVPYXV5ACyxczHF1Q4YGOm",
                        "residueAlphabet": "aa"
                      },
                      "start": 0,
                      "end": 1807,
                      "sequence": null
                    },
                    "relations": [],
                    "matchCharacteristic": {
                      "primaryCoding": {
                        "code": "is_within",
                        "system": "ga4gh-gks-term:location-match"
                      }
                    }
                  },
                  {
                    "type": "FeatureContextConstraint",
                    "featureContext": {
                      "id": "gene:hgnc:12363",
                      "conceptType": "Gene",
                      "name": "TSC2",
                      "primaryCoding": {
                        "id": "coding:hgnc:12363",
                        "code": "HGNC:12363",
                        "system": "https://genenames.org",
                        "iris": [
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                        ]
                      },
                      "mappings": [
                        {
                          "relation": "exactMatch",
                          "coding": {
                            "id": "coding:ensembl:ensg00000103197",
                            "code": "ENSG00000103197",
                            "system": "https://www.ensembl.org",
                            "iris": [
                              "https://www.ensembl.org/id/ENSG00000103197"
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                          }
                        },
                        {
                          "relation": "exactMatch",
                          "coding": {
                            "id": "coding:ncbi:7249",
                            "code": "7249",
                            "system": "https://www.ncbi.nlm.nih.gov/gene",
                            "iris": [
                              "https://www.ncbi.nlm.nih.gov/gene/7249"
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                          }
                        },
                        {
                          "relation": "relatedMatch",
                          "coding": {
                            "id": "coding:refseq:NM_000548.5",
                            "code": "NM_000548.5",
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                            "iris": [
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                        }
                      ]
                    }
                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Somatic variant"
                  },
                  {
                    "name": "chromosome",
                    "value": "16"
                  },
                  {
                    "name": "start_position",
                    "value": null
                  },
                  {
                    "name": "end_position",
                    "value": null
                  },
                  {
                    "name": "reference_allele",
                    "value": null
                  },
                  {
                    "name": "alternate_allele",
                    "value": null
                  },
                  {
                    "name": "cdna_change",
                    "value": null
                  },
                  {
                    "name": "protein_change",
                    "value": null
                  },
                  {
                    "name": "variant_annotation",
                    "value": null
                  },
                  {
                    "name": "exon",
                    "value": null
                  },
                  {
                    "name": "rsid",
                    "value": null
                  },
                  {
                    "name": "hgvsg",
                    "value": null
                  },
                  {
                    "name": "hgvsc",
                    "value": null
                  },
                  {
                    "name": "requires_oncogenic",
                    "value": true
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}