{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:468 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A468",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001896,
    "timestamp_received": "2026-09-25T00:12:44.746852+00:00Z",
    "timestamp_returned": "2026-09-25T00:12:44.748748+00:00Z",
    "trace_id": "87854138-09a6-41a2-a242-2058aa533eb6"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:468",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:HGSFT",
        "conceptType": "Disease",
        "name": "High-Grade Serous Fallopian Tube Cancer",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:oncotree:HGSFT",
          "code": "HGSFT",
          "name": "High-Grade Serous Fallopian Tube Cancer",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=HGSFT"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C102566",
        "conceptType": "Therapy",
        "name": "Mirvetuximab soravtansine",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:2621548",
              "code": "2621548",
              "name": "mirvetuximab soravtansine",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2621548"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:741947",
              "code": "741947",
              "name": "mirvetuximab soravtansine",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/741947"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "Folate receptor-alpha inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Chemotherapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C102566",
          "code": "C102566",
          "name": "Mirvetuximab Soravtansine",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C102566"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:153",
              "present": true,
              "subject": {
                "id": "bmkr:153",
                "type": "CategoricalVariant",
                "name": "FOLR1 positive",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "FOLR1"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Positive"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}