{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:471 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A471",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001773,
    "timestamp_received": "2026-09-25T01:15:52.367668+00:00Z",
    "timestamp_returned": "2026-09-25T01:15:52.369441+00:00Z",
    "trace_id": "3ac98dda-e68f-4cfa-93f1-81d1396e531b"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:471",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:LGGNOS",
        "conceptType": "Disease",
        "name": "Low-Grade Glioma, NOS",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:oncotree:LGGNOS",
          "code": "LGGNOS",
          "name": "Low-Grade Glioma, NOS",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=LGGNOS"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C106254",
        "conceptType": "Therapy",
        "name": "Tovorafenib",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:2682434",
              "code": "2682434",
              "name": "tovorafenib",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2682434"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:1734345",
              "code": "1734345",
              "name": "tovorafenib",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/1734345"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "B-RAF inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C106254",
          "code": "C106254",
          "name": "Tovorafenib",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C106254"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:154",
              "present": true,
              "subject": {
                "id": "bmkr:154",
                "type": "CategoricalVariant",
                "name": "v::BRAF",
                "constraints": [
                  {
                    "type": "AdjacencyConstraint",
                    "orderKnown": false,
                    "adjoinedElements": [
                      {
                        "id": "gene:hgnc:1097",
                        "conceptType": "Gene",
                        "name": "BRAF",
                        "primaryCoding": {
                          "id": "coding:hgnc:1097",
                          "code": "HGNC:1097",
                          "system": "https://genenames.org",
                          "iris": [
                            "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1097"
                          ]
                        },
                        "mappings": [
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ensembl:ensg00000157764",
                              "code": "ENSG00000157764",
                              "system": "https://www.ensembl.org",
                              "iris": [
                                "https://www.ensembl.org/id/ENSG00000157764"
                              ]
                            }
                          },
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ncbi:673",
                              "code": "673",
                              "system": "https://www.ncbi.nlm.nih.gov/gene",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/gene/673"
                              ]
                            }
                          },
                          {
                            "relation": "relatedMatch",
                            "coding": {
                              "id": "coding:refseq:NM_004333.6",
                              "code": "NM_004333.6",
                              "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/nuccore/NM_004333.6"
                              ]
                            }
                          }
                        ]
                      },
                      {
                        "type": "UnspecifiedElement"
                      }
                    ]
                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Gene fusion"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}