{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:479 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A479", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001866, "timestamp_received": "2026-09-25T00:12:51.368532+00:00Z", "timestamp_returned": "2026-09-25T00:12:51.370398+00:00Z", "trace_id": "08624eca-72db-4833-b314-03287a8d1416" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:479", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:ASTR", "conceptType": "Disease", "name": "Astrocytoma", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:ASTR", "code": "ASTR", "name": "Astrocytoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=ASTR" ] } }, "objectTherapeutic": { "id": "tx:ncit:C152914", "conceptType": "Therapy", "name": "Vorasidenib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2690647", "code": "2690647", "name": "vorasidenib", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2690647" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1735000", "code": "1735000", "name": "vorasidenib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1735000" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "IDH1/2 inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C152914", "code": "C152914", "name": "Vorasidenib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C152914" ] } }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:74", "present": true, "subject": { "id": "bmkr:74", "type": "CategoricalVariant", "name": "IDH1 p.R132C", "constraints": [ { "type": "DefiningAlleleConstraint", "allele": { "id": "ga4gh:VA.lAST62ntkEaXy6RDDOF1V4C3jd-jaAJ5", "type": "Allele", "name": "NP_005887.2:p.Arg132Cys", "aliases": [ "NP_005887.2:p.R132C", "IDH1 p.R132C" ], "description": "VRS variation of NP_005887.2:p.Arg132Cys", "digest": "lAST62ntkEaXy6RDDOF1V4C3jd-jaAJ5", "expressions": [ { "syntax": "hgvs.p", "value": "NP_005887.2:p.Arg132Cys", "extensions": [ { "name": "hgvs.p_short", "value": "p.R132C" } ] } ], "location": { "id": "ga4gh:SL.c1wumiCWSPL2vagoeYClRf5Z1SuyrIdx", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Amino acid position 132 of the Refseq protein NP_005887.2, which is the protein product of the MANE Select coding transcript for IDH1 (refseq:NM_005896.4).", "digest": "c1wumiCWSPL2vagoeYClRf5Z1SuyrIdx", "sequenceReference": { "id": "ga4gh:SQ.VZMxTY2iB2G_EuwlpVZ0AnX6R-am08GZ", "type": "SequenceReference", "name": "NP_005887.2", "aliases": [ "ensembl:ENSP00000260985.2", "ga4gh:SQ.VZMxTY2iB2G_EuwlpVZ0AnX6R-am08GZ", "refseq:NP_005887.2" ], "description": "The protein product of the MANE Select coding transcript for IDH1 (refseq:NM_005896.4), corresponding to the Refseq protein accession NP_005887.2.", "moleculeType": "protein", "refgetAccession": "SQ.VZMxTY2iB2G_EuwlpVZ0AnX6R-am08GZ", "residueAlphabet": "aa" }, "start": 131, "end": 132, "sequence": "R" }, "state": { "type": "LiteralSequenceExpression", "sequence": "C" } }, "relations": [] }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:5382", "conceptType": "Gene", "name": "IDH1", "primaryCoding": { "id": "coding:hgnc:5382", "code": "HGNC:5382", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5382" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000138413", "code": "ENSG00000138413", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000138413" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:3417", "code": "3417", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/3417" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_005896.4", "code": "NM_005896.4", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_005896.4" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "2" }, { "name": "start_position", "value": 209113113 }, { "name": "end_position", "value": 209113113 }, { "name": "reference_allele", "value": "G" }, { "name": "alternate_allele", "value": "A" }, { "name": "cdna_change", "value": "c.394C>T" }, { "name": "protein_change", "value": "p.R132C" }, { "name": "variant_annotation", "value": "Missense" }, { "name": "exon", "value": 4 }, { "name": "rsid", "value": "rs121913499" }, { "name": "hgvsg", "value": "2:g.209113113G>A" }, { "name": "hgvsc", "value": "ENST00000345146.2:c.394C>T" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }