{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:552 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A552",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001926,
    "timestamp_received": "2026-09-25T05:26:52.360624+00:00Z",
    "timestamp_returned": "2026-09-25T05:26:52.362550+00:00Z",
    "trace_id": "fe6bb892-02b9-4350-ba59-d1cdda46953b"
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  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:552",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:NSCLC",
        "conceptType": "Disease",
        "name": "Non-Small Cell Lung Cancer",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:oncotree:NSCLC",
          "code": "NSCLC",
          "name": "Non-Small Cell Lung Cancer",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=NSCLC"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C128799",
        "conceptType": "Therapy",
        "name": "Trastuzumab deruxtecan",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:2267582",
              "code": "2267582",
              "name": "trastuzumab deruxtecan",
              "system": "RxNorm",
              "systemVersion": "20250602",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2267582"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:3666979",
              "code": "3666979",
              "name": "Trastuzumab deruxtecan",
              "system": "OMOP",
              "systemVersion": "v20250827",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/3666979"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:sctid:838469001",
              "code": "838469001",
              "name": "Trastuzumab deruxtecan",
              "system": "SNOMED",
              "systemVersion": "2026-03-01",
              "iris": [
                "https://browser.ihtsdotools.org/?perspective=full&conceptId1=838469001&edition=MAIN/2026-03-01&release=&languages=en"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:37498192",
              "code": "37498192",
              "name": "trastuzumab deruxtecan",
              "system": "OMOP",
              "systemVersion": "v20250827",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/37498192"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "HER2 inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C128799",
          "code": "C128799",
          "name": "Trastuzumab Deruxtecan",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C128799"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:21",
              "present": true,
              "subject": {
                "id": "bmkr:21",
                "type": "CategoricalVariant",
                "name": "ERBB2 amplification",
                "constraints": [
                  {
                    "type": "FeatureContextConstraint",
                    "featureContext": {
                      "id": "gene:hgnc:3430",
                      "conceptType": "Gene",
                      "name": "ERBB2",
                      "primaryCoding": {
                        "id": "coding:hgnc:3430",
                        "code": "HGNC:3430",
                        "system": "https://genenames.org",
                        "iris": [
                          "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3430"
                        ]
                      },
                      "mappings": [
                        {
                          "relation": "exactMatch",
                          "coding": {
                            "id": "coding:ensembl:ensg00000141736",
                            "code": "ENSG00000141736",
                            "system": "https://www.ensembl.org",
                            "iris": [
                              "https://www.ensembl.org/id/ENSG00000141736"
                            ]
                          }
                        },
                        {
                          "relation": "exactMatch",
                          "coding": {
                            "id": "coding:ncbi:2064",
                            "code": "2064",
                            "system": "https://www.ncbi.nlm.nih.gov/gene",
                            "iris": [
                              "https://www.ncbi.nlm.nih.gov/gene/2064"
                            ]
                          }
                        },
                        {
                          "relation": "relatedMatch",
                          "coding": {
                            "id": "coding:refseq:NM_004448.4",
                            "code": "NM_004448.4",
                            "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                            "iris": [
                              "https://www.ncbi.nlm.nih.gov/nuccore/NM_004448.4"
                            ]
                          }
                        }
                      ]
                    }
                  },
                  {
                    "type": "CopyChangeConstraint",
                    "copyChange": "gain"
                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Copy number"
                  },
                  {
                    "name": "cytoband",
                    "value": null
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}