{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:57 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A57", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001777, "timestamp_received": "2026-09-25T00:12:24.745171+00:00Z", "timestamp_returned": "2026-09-25T00:12:24.746948+00:00Z", "trace_id": "d01c9c1f-8120-42d9-b145-eeb918eaef3d" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:57", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:BRCA", "conceptType": "Disease", "name": "Invasive Breast Carcinoma", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:BRCA", "code": "BRCA", "name": "Invasive Breast Carcinoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=BRCA" ] } }, "objectTherapeutic": { "id": "txgrp:12", "membershipOperator": "AND", "therapies": [ { "id": "tx:ncit:C102564", "conceptType": "Therapy", "name": "Capivasertib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2669967", "code": "2669967", "name": "capivasertib", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ 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"mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:282357", "code": "282357", "name": "fulvestrant", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=282357" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4300255", "code": "4300255", "name": "Fulvestrant", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4300255" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:385519002", "code": "385519002", "name": "Fulvestrant", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=385519002&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1304044", "code": "1304044", "name": "fulvestrant", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1304044" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "Estrogen receptor inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Hormone therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C1379", "code": "C1379", "name": "Fulvestrant", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1379" ] } } ] }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:1", "present": true, "subject": { "id": "bmkr:1", "type": "CategoricalVariant", "name": "ER positive", "constraints": [], "extensions": [ { "name": "biomarker_type", "value": "Protein expression" }, { "name": "marker", "value": "Estrogen receptor (ER)" }, { "name": "unit", "value": "status" }, { "name": "equality", "value": "=" }, { "name": "value", "value": "Positive" } ] } }, { "id": "bmkr.criterion:2", "present": true, "subject": { "id": "bmkr:2", "type": "CategoricalVariant", "name": "HER2-negative", "constraints": [], "extensions": [ { "name": "biomarker_type", "value": "Protein expression" }, { "name": "marker", "value": "Human epidermal growth factor receptor 2 (HER2)" }, { "name": "unit", "value": "status" }, { "name": "equality", "value": "=" }, { "name": "value", "value": "Negative" } ] } }, { "id": "bmkr.criterion:3", "present": true, "subject": { "id": "bmkr:3", "type": "CategoricalVariant", "name": "PR positive", "constraints": [], "extensions": [ { "name": "biomarker_type", "value": "Protein expression" }, { "name": "marker", "value": "Progesterone receptor (PR)" }, { "name": "unit", "value": "status" }, { "name": "equality", "value": "=" }, { "name": "value", "value": "Positive" } ] } }, { "id": "bmkr.criterion:90", "present": true, "subject": { "id": "bmkr:90", "type": "CategoricalVariant", "name": "AKT1 Somatic variants", "constraints": [ { "type": "DefiningLocationConstraint", "location": { "id": "ga4gh:SL.hLCi0ZPwR6YUb62J6HgjZMjEVAyULOnu", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Sequence spanning the length of refseq:NP_001369359.1, the protein product of the MANE Select coding transcript for AKT1 (refseq:NM_001382430.1).", "digest": "hLCi0ZPwR6YUb62J6HgjZMjEVAyULOnu", "sequenceReference": { "id": "ga4gh:SQ.GTSPIWYvuDZU59cW1RECFEU1FMiKdEyc", "type": "SequenceReference", "name": "NP_001369359.1", "aliases": [ "ensembl:ENSP00000270202.4", "ga4gh:SQ.GTSPIWYvuDZU59cW1RECFEU1FMiKdEyc", "refseq:NP_001369359.1" ], "description": "The protein product of the MANE Select coding transcript for AKT1 (refseq:NM_001382430.1), corresponding to the Refseq protein accession NP_001369359.1.", "moleculeType": "protein", "refgetAccession": "SQ.GTSPIWYvuDZU59cW1RECFEU1FMiKdEyc", "residueAlphabet": "aa" }, "start": 0, "end": 480, "sequence": null }, "relations": [], "matchCharacteristic": { "primaryCoding": { "code": "is_within", "system": "ga4gh-gks-term:location-match" } } }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:391", "conceptType": "Gene", "name": "AKT1", "primaryCoding": { "id": "coding:hgnc:391", "code": "HGNC:391", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:391" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000142208", "code": "ENSG00000142208", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000142208" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:207", "code": "207", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/207" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_001382430.1", "code": "NM_001382430.1", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_001382430.1" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "14" }, { "name": "start_position", "value": null }, { "name": "end_position", "value": null }, { "name": "reference_allele", "value": null }, { "name": "alternate_allele", "value": null }, { "name": "cdna_change", "value": null }, { "name": "protein_change", "value": null }, { "name": "variant_annotation", "value": null }, { "name": "exon", "value": null }, { "name": "rsid", "value": null }, { "name": "hgvsg", "value": null }, { "name": "hgvsc", "value": null }, { "name": "requires_oncogenic", "value": true } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }