{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:654 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A654", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001785, "timestamp_received": "2026-09-25T05:26:52.647195+00:00Z", "timestamp_returned": "2026-09-25T05:26:52.648980+00:00Z", "trace_id": "84fcbf50-e4ec-4446-9ba5-82ab4ada3265" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:654", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:BRCA", "conceptType": "Disease", "name": "Invasive Breast Carcinoma", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:BRCA", "code": "BRCA", "name": "Invasive Breast Carcinoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=BRCA" ] } }, "objectTherapeutic": { "id": "txgrp:5", "membershipOperator": "AND", "therapies": [ { "id": "tx:ncit:C94214", "conceptType": "Therapy", "name": "Alpelisib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2169285", "code": "2169285", "name": "alpelisib", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ 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"value": "status" }, { "name": "equality", "value": "=" }, { "name": "value", "value": "Positive" } ] } }, { "id": "bmkr.criterion:87", "present": true, "subject": { "id": "bmkr:87", "type": "CategoricalVariant", "name": "PIK3CA Somatic variants", "constraints": [ { "type": "DefiningLocationConstraint", "location": { "id": "ga4gh:SL.LEkzFRUTltP1kQuWVY4p2i5A_aK1SJI5", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Sequence spanning the length of refseq:NP_006209.2, the protein product of the MANE Select coding transcript for PIK3CA (refseq:NM_006218.4).", "digest": "LEkzFRUTltP1kQuWVY4p2i5A_aK1SJI5", "sequenceReference": { "id": "ga4gh:SQ.km8C9FORJbErpAh7Ub63pZLUzEm-au9D", "type": "SequenceReference", "name": "NP_006209.2", "aliases": [ "ensembl:ENSP00000263967.3", "ga4gh:SQ.km8C9FORJbErpAh7Ub63pZLUzEm-au9D", "refseq:NP_006209.2" ], "description": "The protein product of the MANE Select coding transcript for PIK3CA (refseq:NM_006218.4), corresponding to the 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"https://www.ncbi.nlm.nih.gov/gene/5290" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_006218.4", "code": "NM_006218.4", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_006218.4" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "7" }, { "name": "start_position", "value": null }, { "name": "end_position", "value": null }, { "name": "reference_allele", "value": null }, { "name": "alternate_allele", "value": null }, { "name": "cdna_change", "value": null }, { "name": "protein_change", "value": null }, { "name": "variant_annotation", "value": null }, { "name": "exon", "value": null }, { "name": "rsid", "value": null }, { "name": "hgvsg", "value": null }, { "name": "hgvsc", "value": null }, { "name": "requires_oncogenic", "value": true } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }