{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:657 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A657", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001794, "timestamp_received": "2026-09-25T05:26:53.572809+00:00Z", "timestamp_returned": "2026-09-25T05:26:53.574603+00:00Z", "trace_id": "d379788b-2d20-4618-8a08-7756bc33ef42" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:657", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:THME", "conceptType": "Disease", "name": "Medullary Thyroid Cancer", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:THME", "code": "THME", "name": "Medullary Thyroid Cancer", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=THME" ] } }, "objectTherapeutic": { "id": "tx:ncit:C134987", "conceptType": "Therapy", "name": "Selpercatinib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2370147", "code": "2370147", "name": "selpercatinib", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2370147" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1145791", "code": "1145791", "name": "selpercatinib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1145791" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:876841001", "code": "876841001", "name": "Selpercatinib", "system": "SNOMED", "systemVersion": "2025-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=876841001&edition=MAIN/2025-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:618816", "code": "618816", "name": "Selpercatinib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/618816" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "RET inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C134987", "code": "C134987", "name": "Selpercatinib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C134987" ] } }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:60", "present": true, "subject": { "id": "bmkr:60", "type": "CategoricalVariant", "name": "RET p.M918T", "constraints": [ { "type": "DefiningAlleleConstraint", "allele": { "id": "ga4gh:VA.hEybNB_CeKflfFhT5AKOU5i1lgZPP-aS", "type": "Allele", "name": "NP_066124.1:p.Met918Thr", "aliases": [ "NP_066124.1:p.M918T", "RET p.M918T" ], "description": "VRS variation of NP_066124.1:p.Met918Thr", "digest": "hEybNB_CeKflfFhT5AKOU5i1lgZPP-aS", "expressions": [ { "syntax": "hgvs.p", "value": "NP_066124.1:p.Met918Thr", "extensions": [ { "name": "hgvs.p_short", "value": "p.M918T" } ] } ], "location": { "id": "ga4gh:SL.oIeqSfOEuqO7KNOPt8YUIa9vo1f6yMao", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Amino acid position 918 of the Refseq protein NP_066124.1, which is the protein product of the MANE Select coding transcript for RET (refseq:NM_020975.6).", "digest": "oIeqSfOEuqO7KNOPt8YUIa9vo1f6yMao", "sequenceReference": { "id": "ga4gh:SQ.jMu9-ItXSycQsm4hyABeW_UfSNRXRVnl", "type": "SequenceReference", "name": "NP_066124.1", "aliases": [ "ensembl:ENSP00000347942.3", "ga4gh:SQ.jMu9-ItXSycQsm4hyABeW_UfSNRXRVnl", "refseq:NP_066124.1" ], "description": "The protein product of the MANE Select coding transcript for RET (refseq:NM_020975.6), corresponding to the Refseq protein accession NP_066124.1.", "moleculeType": "protein", "refgetAccession": "SQ.jMu9-ItXSycQsm4hyABeW_UfSNRXRVnl", "residueAlphabet": "aa" }, "start": 917, "end": 918, "sequence": "M" }, "state": { "type": "LiteralSequenceExpression", "sequence": "T" } }, "relations": [] }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:9967", "conceptType": "Gene", "name": "RET", "primaryCoding": { "id": "coding:hgnc:9967", "code": "HGNC:9967", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9967" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000165731", "code": "ENSG00000165731", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000165731" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:5979", "code": "5979", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/5979" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_020975.6", "code": "NM_020975.6", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_020975.6" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "10" }, { "name": "start_position", "value": 43617416 }, { "name": "end_position", "value": 43617416 }, { "name": "reference_allele", "value": "T" }, { "name": "alternate_allele", "value": "C" }, { "name": "cdna_change", "value": "c.2753T>C" }, { "name": "protein_change", "value": "p.M918T" }, { "name": "variant_annotation", "value": "Missense" }, { "name": "exon", "value": 16 }, { "name": "rsid", "value": "rs74799832" }, { "name": "hgvsg", "value": "10:g.43617416T>C" }, { "name": "hgvsc", "value": "ENST00000355710.3:c.2753T>C" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }