{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:658 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A658",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001812,
    "timestamp_received": "2026-09-25T05:26:51.850711+00:00Z",
    "timestamp_returned": "2026-09-25T05:26:51.852523+00:00Z",
    "trace_id": "2a61ee4a-7815-41ae-9a3a-e6191129ab43"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:658",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:MPN",
        "conceptType": "Disease",
        "name": "Myeloproliferative Neoplasm",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": false,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:oncotree:MPN",
          "code": "MPN",
          "name": "Myeloproliferative Neoplasm",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=MPN"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C2668",
        "conceptType": "Therapy",
        "name": "Lenalidomide",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:342369",
              "code": "342369",
              "name": "lenalidomide",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=342369"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:19026972",
              "code": "19026972",
              "name": "lenalidomide",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/19026972"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:sctid:421471009",
              "code": "421471009",
              "name": "Lenalidomide",
              "system": "SNOMED",
              "systemVersion": "2025-03-01",
              "iris": [
                "https://browser.ihtsdotools.org/?perspective=full&conceptId1=421471009&edition=MAIN/2025-03-01&release=&languages=en"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:4222840",
              "code": "4222840",
              "name": "Lenalidomide",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/4222840"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "Angiogenesis inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Chemotherapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C2668",
          "code": "C2668",
          "name": "Lenalidomide",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2668"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:61",
              "present": true,
              "subject": {
                "id": "bmkr:61",
                "type": "CategoricalVariant",
                "name": "5q deletion",
                "constraints": [
                  {
                    "type": "DefiningLocationConstraint",
                    "location": {
                      "id": "ga4gh:SL.KteBPIw-ySQLUSuG8gVPuVJnZW7kF7Js",
                      "type": "SequenceLocation",
                      "name": null,
                      "aliases": [],
                      "description": "The q arm of GRCh38 chromosome 5 (NC_000005.10), from the end of the centromere to the end of the chromosome.",
                      "digest": "KteBPIw-ySQLUSuG8gVPuVJnZW7kF7Js",
                      "sequenceReference": {
                        "id": "ga4gh:SQ.aUiQCzCPZ2d0csHbMSbh2NzInhonSXwI",
                        "type": "SequenceReference",
                        "name": "NC_000005.10",
                        "aliases": [
                          "ga4gh:SQ.aUiQCzCPZ2d0csHbMSbh2NzInhonSXwI",
                          "refseq:NC_000005.10"
                        ],
                        "description": "GRCh38 chromosome 5 (RefSeq NC_000005.10).",
                        "moleculeType": "genomic",
                        "refgetAccession": "SQ.aUiQCzCPZ2d0csHbMSbh2NzInhonSXwI",
                        "residueAlphabet": "na"
                      },
                      "start": 50059807,
                      "end": 181538259,
                      "sequence": null
                    },
                    "relations": [],
                    "matchCharacteristic": {
                      "primaryCoding": {
                        "code": "is_within",
                        "system": "ga4gh-gks-term:location-match"
                      }
                    }
                  },
                  {
                    "type": "CopyChangeConstraint",
                    "copyChange": "loss"
                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Copy number (arm level)"
                  },
                  {
                    "name": "chromosome",
                    "value": "5"
                  },
                  {
                    "name": "arm",
                    "value": "q"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}