{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:659 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A659",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001918,
    "timestamp_received": "2026-09-25T04:53:13.852574+00:00Z",
    "timestamp_returned": "2026-09-25T04:53:13.854492+00:00Z",
    "trace_id": "90334161-4099-44ac-a4fc-657432df78a5"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:659",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:CML",
        "conceptType": "Disease",
        "name": "Chronic Myelogenous Leukemia",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": false,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:oncotree:CML",
          "code": "CML",
          "name": "Chronic Myelogenous Leukemia",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=CML"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C114494",
        "conceptType": "Therapy",
        "name": "Asciminib",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:2584304",
              "code": "2584304",
              "name": "asciminib",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2584304"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:702133",
              "code": "702133",
              "name": "asciminib",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/702133"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "BCR-ABL inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C114494",
          "code": "C114494",
          "name": "Asciminib",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C114494"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:15",
              "present": false,
              "subject": {
                "id": "bmkr:12",
                "type": "CategoricalVariant",
                "name": "BCR::ABL1",
                "constraints": [
                  {
                    "type": "AdjacencyConstraint",
                    "orderKnown": true,
                    "adjoinedElements": [
                      {
                        "id": "gene:hgnc:1014",
                        "conceptType": "Gene",
                        "name": "BCR",
                        "primaryCoding": {
                          "id": "coding:hgnc:1014",
                          "code": "HGNC:1014",
                          "system": "https://genenames.org",
                          "iris": [
                            "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1014"
                          ]
                        },
                        "mappings": [
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ensembl:ensg00000186716",
                              "code": "ENSG00000186716",
                              "system": "https://www.ensembl.org",
                              "iris": [
                                "https://www.ensembl.org/id/ENSG00000186716"
                              ]
                            }
                          },
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ncbi:613",
                              "code": "613",
                              "system": "https://www.ncbi.nlm.nih.gov/gene",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/gene/613"
                              ]
                            }
                          },
                          {
                            "relation": "relatedMatch",
                            "coding": {
                              "id": "coding:refseq:NM_004327.4",
                              "code": "NM_004327.4",
                              "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/nuccore/NM_004327.4"
                              ]
                            }
                          }
                        ]
                      },
                      {
                        "id": "gene:hgnc:76",
                        "conceptType": "Gene",
                        "name": "ABL1",
                        "primaryCoding": {
                          "id": "coding:hgnc:76",
                          "code": "HGNC:76",
                          "system": "https://genenames.org",
                          "iris": [
                            "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:76"
                          ]
                        },
                        "mappings": [
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ensembl:ensg00000097007",
                              "code": "ENSG00000097007",
                              "system": "https://www.ensembl.org",
                              "iris": [
                                "https://www.ensembl.org/id/ENSG00000097007"
                              ]
                            }
                          },
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ncbi:25",
                              "code": "25",
                              "system": "https://www.ncbi.nlm.nih.gov/gene",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/gene/25"
                              ]
                            }
                          },
                          {
                            "relation": "relatedMatch",
                            "coding": {
                              "id": "coding:refseq:NM_005157.6",
                              "code": "NM_005157.6",
                              "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/nuccore/NM_005157.6"
                              ]
                            }
                          }
                        ]
                      }
                    ]
                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Gene fusion"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}