{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:674 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A674", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001763, "timestamp_received": "2026-09-25T05:27:17.633026+00:00Z", "timestamp_returned": "2026-09-25T05:27:17.634789+00:00Z", "trace_id": "8e72a34c-2ffa-4ffe-bcf3-1f9d5fbe67c0" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:674", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:NSCLC", "conceptType": "Disease", "name": "Non-Small Cell Lung Cancer", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": true, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:NSCLC", "code": "NSCLC", "name": "Non-Small Cell Lung Cancer", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=NSCLC" ] } }, "objectTherapeutic": { "id": "txgrp:134", "membershipOperator": "AND", "therapies": [ { "id": "tx:ncit:C106250", "conceptType": "Therapy", "name": "Atezolizumab", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:1792776", "code": "1792776", "name": "atezolizumab", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": 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mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Immunotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C106250", "code": "C106250", "name": "Atezolizumab", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C106250" ] } }, { "id": "tx:ncit:C2039", "conceptType": "Therapy", "name": "Bevacizumab", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:253337", "code": "253337", "name": "bevacizumab", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=253337" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4247981", "code": "4247981", "name": "Bevacizumab", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4247981" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:409406007", "code": "409406007", "name": "Bevacizumab", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=409406007&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1397141", "code": "1397141", "name": "bevacizumab", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1397141" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "VEGF inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C2039", "code": "C2039", "name": "Bevacizumab", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2039" ] } }, { "id": "tx:ncit:C1282", "conceptType": "Therapy", "name": "Carboplatin", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:40048", "code": "40048", "name": "carboplatin", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=40048" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4299846", "code": "4299846", "name": "Carboplatin", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4299846" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:386905002", "code": "386905002", "name": "Carboplatin", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ 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"conceptType": "Therapy", "name": "Paclitaxel", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:56946", "code": "56946", "name": "paclitaxel", "system": "RxNorm", "systemVersion": "20250602", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=56946" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:4306859", "code": "4306859", "name": "Paclitaxel", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/4306859" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:sctid:387374002", "code": "387374002", "name": "Paclitaxel", "system": "SNOMED", "systemVersion": "2026-03-01", "iris": [ "https://browser.ihtsdotools.org/?perspective=full&conceptId1=387374002&edition=MAIN/2026-03-01&release=&languages=en" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:1378382", "code": "1378382", "name": "paclitaxel", "system": "OMOP", "systemVersion": "v20250827", "iris": [ "https://athena.ohdsi.org/search-terms/terms/1378382" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "Taxane-based chemotherapy" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Chemotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C1411", "code": "C1411", "name": "Paclitaxel", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1411" ] } } ] }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:8", "present": true, "subject": { "id": "bmkr:8", "type": "CategoricalVariant", "name": "v::ALK", "constraints": [ { "type": "AdjacencyConstraint", "orderKnown": false, "adjoinedElements": [ { "id": "gene:hgnc:427", "conceptType": "Gene", "name": "ALK", "primaryCoding": { "id": "coding:hgnc:427", "code": "HGNC:427", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:427" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000171094", "code": "ENSG00000171094", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000171094" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:238", "code": "238", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/238" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_004304.5", "code": "NM_004304.5", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_004304.5" ] } } ] }, { "type": "UnspecifiedElement" } ] } ], "extensions": [ { "name": "biomarker_type", "value": "Gene fusion" } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }