{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:713 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A713", "status": "success", "status_code": 200, "timestamp_elapsed": 0.002025, "timestamp_received": "2026-09-25T04:53:16.148812+00:00Z", "timestamp_returned": "2026-09-25T04:53:16.150837+00:00Z", "trace_id": "4ed3cb57-97ce-4e25-820b-fd841ed17307" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:713", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:ncit:C3163", "conceptType": "Disease", "name": "Chronic Lymphocytic Leukemia", "mappings": [ { "relation": "broadMatch", "coding": { "id": "coding:oncotree:CLLSLL", "code": "CLLSLL", "name": "Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=CLLSLL" ] } } ], "extensions": [ { "name": "solid_tumor", "value": false, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:ncit:C3163", "code": "C3163", "name": "Chronic Lymphocytic Leukemia", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3163" ] } }, "objectTherapeutic": { "id": 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"coding:omop:46271986", "code": "46271986", "name": "Idelalisib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/46271986" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "PI3K/AKT/mTOR inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C78825", "code": "C78825", "name": "Idelalisib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C78825" ] } }, { "id": "tx:ncit:C1702", "conceptType": "Therapy", "name": "Rituximab", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:121191", "code": "121191", "name": "rituximab", "system": 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therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Immunotherapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C1702", "code": "C1702", "name": "Rituximab", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1702" ] } } ] }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:80", "present": true, "subject": { "id": "bmkr:80", "type": "CategoricalVariant", "name": "TP53 Somatic variants", "constraints": [ { "type": "DefiningLocationConstraint", "location": { "id": "ga4gh:SL.-oJnRI__rvXIYjpwdDBxIjQ0O8Qm-Imi", "type": "SequenceLocation", "name": null, "aliases": [], "description": "Sequence spanning the length of refseq:NP_000537.3, the protein product of the MANE Select coding transcript for TP53 (refseq:NM_000546.6).", "digest": "-oJnRI__rvXIYjpwdDBxIjQ0O8Qm-Imi", "sequenceReference": { "id": "ga4gh:SQ.KAxM06sYzBF6zFftFaYq9E_18wsnn7al", "type": "SequenceReference", "name": "NP_000537.3", "aliases": [ "ensembl:ENSP00000269305.4", "ga4gh:SQ.KAxM06sYzBF6zFftFaYq9E_18wsnn7al", "refseq:NP_000537.3" ], "description": "The protein product of the MANE Select coding transcript for TP53 (refseq:NM_000546.6), corresponding to the Refseq protein accession NP_000537.3.", "moleculeType": "protein", "refgetAccession": "SQ.KAxM06sYzBF6zFftFaYq9E_18wsnn7al", "residueAlphabet": "aa" }, "start": 0, "end": 393, "sequence": null }, "relations": [], "matchCharacteristic": { "primaryCoding": { "code": "is_within", "system": "ga4gh-gks-term:location-match" } } }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:11998", "conceptType": "Gene", "name": "TP53", "primaryCoding": { "id": "coding:hgnc:11998", "code": "HGNC:11998", "system": "https://genenames.org", "iris": [ 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null }, { "name": "cdna_change", "value": null }, { "name": "protein_change", "value": null }, { "name": "variant_annotation", "value": null }, { "name": "exon", "value": null }, { "name": "rsid", "value": null }, { "name": "hgvsg", "value": null }, { "name": "hgvsc", "value": null }, { "name": "requires_oncogenic", "value": false } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }