{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:743 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A743",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.00185,
    "timestamp_received": "2026-09-25T05:26:58.862432+00:00Z",
    "timestamp_returned": "2026-09-25T05:26:58.864282+00:00Z",
    "trace_id": "f82a2e71-09b2-4a27-8876-1f8c3144519d"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:743",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:ncit:C3163",
        "conceptType": "Disease",
        "name": "Chronic Lymphocytic Leukemia",
        "mappings": [
          {
            "relation": "broadMatch",
            "coding": {
              "id": "coding:oncotree:CLLSLL",
              "code": "CLLSLL",
              "name": "Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma",
              "system": "https://oncotree.mskcc.org",
              "systemVersion": "oncotree_2021_11_02",
              "iris": [
                "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=CLLSLL"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": false,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C3163",
          "code": "C3163",
          "name": "Chronic Lymphocytic Leukemia",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3163"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C141428",
        "conceptType": "Therapy",
        "name": "Zanubrutinib",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:2262435",
              "code": "2262435",
              "name": "zanubrutinib",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2262435"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:37497691",
              "code": "37497691",
              "name": "zanubrutinib",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/37497691"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:sctid:830162004",
              "code": "830162004",
              "name": "Zanubrutinib",
              "system": "SNOMED",
              "systemVersion": "2025-03-01",
              "iris": [
                "https://browser.ihtsdotools.org/?perspective=full&conceptId1=830162004&edition=MAIN/2025-03-01&release=&languages=en"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:3666975",
              "code": "3666975",
              "name": "Zanubrutinib",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/3666975"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "BTK inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C141428",
          "code": "C141428",
          "name": "Zanubrutinib",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C141428"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:84",
              "present": false,
              "subject": {
                "id": "bmkr:82",
                "type": "CategoricalVariant",
                "name": "17p deletion",
                "constraints": [
                  {
                    "type": "DefiningLocationConstraint",
                    "location": {
                      "id": "ga4gh:SL.qfCTfkL3D4_EYfMm-vNUV3gPBn6POGaV",
                      "type": "SequenceLocation",
                      "name": null,
                      "aliases": [],
                      "description": "The p arm of GRCh38 chromosome 17 (NC_000017.11), from the start of the chromosome to the start of the centromere.",
                      "digest": "qfCTfkL3D4_EYfMm-vNUV3gPBn6POGaV",
                      "sequenceReference": {
                        "id": "ga4gh:SQ.dLZ15tNO1Ur0IcGjwc3Sdi_0A6Yf4zm7",
                        "type": "SequenceReference",
                        "name": "NC_000017.11",
                        "aliases": [
                          "ga4gh:SQ.dLZ15tNO1Ur0IcGjwc3Sdi_0A6Yf4zm7",
                          "refseq:NC_000017.11"
                        ],
                        "description": "GRCh38 chromosome 17 (RefSeq NC_000017.11).",
                        "moleculeType": "genomic",
                        "refgetAccession": "SQ.dLZ15tNO1Ur0IcGjwc3Sdi_0A6Yf4zm7",
                        "residueAlphabet": "na"
                      },
                      "start": 0,
                      "end": 22813679,
                      "sequence": null
                    },
                    "relations": [],
                    "matchCharacteristic": {
                      "primaryCoding": {
                        "code": "is_within",
                        "system": "ga4gh-gks-term:location-match"
                      }
                    }
                  },
                  {
                    "type": "CopyChangeConstraint",
                    "copyChange": "loss"
                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Copy number (arm level)"
                  },
                  {
                    "name": "chromosome",
                    "value": "17"
                  },
                  {
                    "name": "arm",
                    "value": "p"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}