{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:787 retrieved successfully",
    "request_url": "https://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A787",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001859,
    "timestamp_received": "2026-11-09T16:15:18.630112Z",
    "timestamp_returned": "2026-11-09T16:15:18.631971Z",
    "trace_id": "89d7ce7c-ee2b-4bc7-b927-1b3ef0262fdf"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://moalmanac.org",
    "last_updated": "2026-10-08"
  },
  "data": [
    {
      "id": "prop:vtxr:787",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:ncit:C9245",
        "conceptType": "Disease",
        "name": "Invasive Breast Carcinoma",
        "mappings": [
          {
            "relation": "exactMatch",
            "coding": {
              "id": "coding:oncotree:BRCA",
              "code": "BRCA",
              "name": "Invasive Breast Carcinoma",
              "system": "https://oncotree.mskcc.org",
              "systemVersion": "oncotree_2025_10_03",
              "iris": [
                "https://oncotree.mskcc.org/?version=oncotree_2025_10_03&field=NAME&search=Invasive+Breast+Carcinoma+%28BRCA%29"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C9245",
          "code": "C9245",
          "name": "Invasive Breast Carcinoma",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "26.08e",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9245"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C1097",
        "conceptType": "Therapy",
        "name": "Exemestane",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:258494",
              "code": "258494",
              "name": "exemestane",
              "system": "RxNorm",
              "systemVersion": "20250602",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=258494"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:1398399",
              "code": "1398399",
              "name": "exemestane",
              "system": "OMOP",
              "systemVersion": "v20250827",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/1398399"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "Aromatase inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Hormone therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C1097",
          "code": "C1097",
          "name": "Exemestane",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "26.08e",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1097"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:1",
              "present": true,
              "subject": {
                "id": "bmkr:1",
                "type": "CategoricalVariant",
                "name": "ER positive",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "Estrogen receptor (ER)"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Positive"
                  }
                ]
              }
            },
            {
              "id": "bmkr.criterion:3",
              "present": true,
              "subject": {
                "id": "bmkr:3",
                "type": "CategoricalVariant",
                "name": "PR positive",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "Progesterone receptor (PR)"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Positive"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}