{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:840 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A840",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001862,
    "timestamp_received": "2026-09-25T00:12:47.352732+00:00Z",
    "timestamp_returned": "2026-09-25T00:12:47.354594+00:00Z",
    "trace_id": "a6b44826-dfab-4757-9512-7ad118b3c5a1"
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  "service": {
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    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
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      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
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        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:APLPMLRARA",
        "conceptType": "Disease",
        "name": "APL with PML-RARA",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": false,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
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          "code": "APLPMLRARA",
          "name": "APL with PML-RARA",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
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          ]
        }
      },
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        "name": "Arsenic trioxide",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:18330",
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              "name": "arsenic trioxide",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
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              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:1333379",
              "code": "1333379",
              "name": "arsenic trioxide",
              "system": "OMOP",
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              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:sctid:72251000",
              "code": "72251000",
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              "system": "SNOMED",
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              "iris": [
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              ]
            }
          },
          {
            "relation": "relatedMatch",
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              "id": "coding:omop:4218959",
              "code": "4218959",
              "name": "Arsenic trioxide",
              "system": "OMOP",
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              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/4218959"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "PML::RARA inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C1005",
          "code": "C1005",
          "name": "Arsenic Trioxide",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
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          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:172",
              "present": true,
              "subject": {
                "id": "bmkr:172",
                "type": "CategoricalVariant",
                "name": "t(15;17)",
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                  {
                    "type": "DefiningLocationConstraint",
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                      "type": "SequenceLocation",
                      "name": null,
                      "aliases": [],
                      "description": "GRCh38 chromosome 15 (NC_000015.10), in its entirety.",
                      "digest": "EZBq61rtMPyE8oKI1VnxE0qxTfwvAIne",
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                        "type": "SequenceReference",
                        "name": "NC_000015.10",
                        "aliases": [
                          "ensembl:15",
                          "ga4gh:SQ.AsXvWL1-2i5U_buw6_niVIxD6zTbAuS6",
                          "refseq:NC_000015.10"
                        ],
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                        "moleculeType": "genomic",
                        "refgetAccession": "SQ.AsXvWL1-2i5U_buw6_niVIxD6zTbAuS6",
                        "residueAlphabet": "na"
                      },
                      "start": 0,
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                      "sequence": null
                    },
                    "relations": [],
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                      "primaryCoding": {
                        "code": "is_within",
                        "system": "ga4gh-gks-term:location-match"
                      }
                    }
                  },
                  {
                    "type": "DefiningLocationConstraint",
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                      "type": "SequenceLocation",
                      "name": null,
                      "aliases": [],
                      "description": "GRCh38 chromosome 17 (NC_000017.11), in its entirety.",
                      "digest": "LlQ30oZsqDqzhy8f4ICLOTVftFbP1pUz",
                      "sequenceReference": {
                        "id": "ga4gh:SQ.dLZ15tNO1Ur0IcGjwc3Sdi_0A6Yf4zm7",
                        "type": "SequenceReference",
                        "name": "NC_000017.11",
                        "aliases": [
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                        "description": "GRCh38 chromosome 17 (RefSeq NC_000017.11).",
                        "moleculeType": "genomic",
                        "refgetAccession": "SQ.dLZ15tNO1Ur0IcGjwc3Sdi_0A6Yf4zm7",
                        "residueAlphabet": "na"
                      },
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                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Translocation"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}