{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:874 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A874",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001918,
    "timestamp_received": "2026-09-25T01:15:45.322752+00:00Z",
    "timestamp_returned": "2026-09-25T01:15:45.324670+00:00Z",
    "trace_id": "b30703f2-980b-427f-8443-edbd785c8b89"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:874",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:ncit:C182151",
        "conceptType": "Disease",
        "name": "Diffuse Midline Glioma",
        "mappings": [
          {
            "relation": "narrowMatch",
            "coding": {
              "id": "coding:oncotree:DIFG",
              "code": "DIFG",
              "name": "Diffuse Glioma",
              "system": "https://oncotree.mskcc.org",
              "systemVersion": "oncotree_2021_11_02",
              "iris": [
                "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=DIFG"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C182151",
          "code": "C182151",
          "name": "Diffuse Midline Glioma",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C182151"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C113792",
        "conceptType": "Therapy",
        "name": "Dordaviprone",
        "mappings": [
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:2721194",
              "code": "2721194",
              "name": "dordaviprone",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
              "iris": [
                "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2721194"
              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:37353901",
              "code": "37353901",
              "name": "dordaviprone",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
                "https://athena.ohdsi.org/search-terms/terms/37353901"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "Protease activation"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C113792",
          "code": "C113792",
          "name": "Dordaviprone",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C113792"
          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:176",
              "present": true,
              "subject": {
                "id": "bmkr:176",
                "type": "CategoricalVariant",
                "name": "H3-3A p.K28M",
                "constraints": [
                  {
                    "type": "DefiningAlleleConstraint",
                    "allele": {
                      "id": "ga4gh:VA.OfwVrrqBRkySvtnpfO30-a5S3_NUw3P6",
                      "type": "Allele",
                      "name": "NP_002098.1:p.Lys28Met",
                      "aliases": [
                        "NP_002098.1:p.K28M",
                        "H3-3A p.K28M"
                      ],
                      "description": "VRS variation of NP_002098.1:p.Lys28Met, generated with the VICC Variation Normalizer",
                      "digest": "OfwVrrqBRkySvtnpfO30-a5S3_NUw3P6",
                      "expressions": [
                        {
                          "syntax": "hgvs.p",
                          "value": "NP_002098.1:p.Lys28Met",
                          "extensions": [
                            {
                              "name": "hgvs.p_short",
                              "value": "p.K28M"
                            }
                          ]
                        }
                      ],
                      "location": {
                        "id": "ga4gh:SL._IRpRraJX9DRf4zdTMt615TYq-_pQaMG",
                        "type": "SequenceLocation",
                        "name": null,
                        "aliases": [],
                        "description": "Amino acid position 28 of the Refseq protein NP_002098.1, which is the protein product of the MANE Select coding transcript for H3-3A (refseq:NM_002107.7).",
                        "digest": "_IRpRraJX9DRf4zdTMt615TYq-_pQaMG",
                        "sequenceReference": {
                          "id": "ga4gh:SQ.2uEiKlgt3rV_axllFiEObLHYBOl2mT38",
                          "type": "SequenceReference",
                          "name": "NP_002098.1",
                          "aliases": [
                            "ensembl:ENSP00000254810.3",
                            "ga4gh:SQ.2uEiKlgt3rV_axllFiEObLHYBOl2mT38",
                            "refseq:NP_002098.1"
                          ],
                          "description": "The protein product of the MANE Select coding transcript for H3-3A (refseq:NM_002107.7), corresponding to the Refseq protein accession NP_002098.1.",
                          "moleculeType": "protein",
                          "refgetAccession": "SQ.2uEiKlgt3rV_axllFiEObLHYBOl2mT38",
                          "residueAlphabet": "aa"
                        },
                        "start": 27,
                        "end": 28,
                        "sequence": "K"
                      },
                      "state": {
                        "type": "LiteralSequenceExpression",
                        "sequence": "M"
                      }
                    },
                    "relations": []
                  },
                  {
                    "type": "FeatureContextConstraint",
                    "featureContext": {
                      "id": "gene:hgnc:4764",
                      "conceptType": "Gene",
                      "name": "H3-3A",
                      "primaryCoding": {
                        "id": "coding:hgnc:4764",
                        "code": "HGNC:4764",
                        "name": "H3-3A",
                        "system": "https://genenames.org",
                        "iris": [
                          "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4764"
                        ]
                      },
                      "mappings": [
                        {
                          "relation": "relatedMatch",
                          "coding": {
                            "id": "coding:ensembl:ensg00000163041",
                            "code": "ENSG00000163041",
                            "system": "https://www.ensembl.org",
                            "iris": [
                              "https://www.ensembl.org/id/ENSG00000163041"
                            ]
                          }
                        },
                        {
                          "relation": "relatedMatch",
                          "coding": {
                            "id": "coding:ncbi:3020",
                            "code": "3020",
                            "system": "https://www.ncbi.nlm.nih.gov/gene",
                            "iris": [
                              "https://www.ncbi.nlm.nih.gov/gene/3020"
                            ]
                          }
                        },
                        {
                          "relation": "relatedMatch",
                          "coding": {
                            "id": "coding:refseq:NM_002107.7",
                            "code": "NM_002107.7",
                            "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                            "iris": [
                              "https://www.ncbi.nlm.nih.gov/nuccore/NM_002107.7"
                            ]
                          }
                        }
                      ]
                    }
                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Somatic variant"
                  },
                  {
                    "name": "chromosome",
                    "value": "1"
                  },
                  {
                    "name": "start_position",
                    "value": 226252135
                  },
                  {
                    "name": "end_position",
                    "value": 226252135
                  },
                  {
                    "name": "reference_allele",
                    "value": "A"
                  },
                  {
                    "name": "alternate_allele",
                    "value": "T"
                  },
                  {
                    "name": "cdna_change",
                    "value": "c.83A>T"
                  },
                  {
                    "name": "protein_change",
                    "value": "p.K28M"
                  },
                  {
                    "name": "variant_annotation",
                    "value": "Missense"
                  },
                  {
                    "name": "exon",
                    "value": "2/4"
                  },
                  {
                    "name": "rsid",
                    "value": "rs1057519903"
                  },
                  {
                    "name": "hgvsg",
                    "value": "1:g.226252135A>T"
                  },
                  {
                    "name": "hgvsc",
                    "value": "NM_002107.7:c.83A>T"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}