{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:877 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A877", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001793, "timestamp_received": "2026-09-25T01:14:56.021936+00:00Z", "timestamp_returned": "2026-09-25T01:14:56.023729+00:00Z", "trace_id": "7c5da96a-ad2b-41e6-8526-9d06b2dc92fc" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:877", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition." }, "conditionQualifier": { "id": "dis:oncotree:AML", "conceptType": "Disease", "name": "Acute Myeloid Leukemia", "mappings": [], "extensions": [ { "name": "solid_tumor", "value": false, "description": "Boolean value for if this tumor type is categorized as a solid tumor." } ], "primaryCoding": { "id": "coding:oncotree:AML", "code": "AML", "name": "Acute Myeloid Leukemia", "system": "https://oncotree.mskcc.org", "systemVersion": "oncotree_2021_11_02", "iris": [ "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=AML" ] } }, "objectTherapeutic": { "id": "tx:ncit:C68936", "conceptType": "Therapy", "name": "Quizartinib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2643048", "code": "2643048", "name": "quizartinib", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2643048" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:746225", "code": "746225", "name": "quizartinib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/746225" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "FLT3 inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types" } ], "primaryCoding": { "id": "coding:ncit:C68936", "code": "C68936", "name": "Quizartinib", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C68936" ] } }, "extensions": [ { "name": "biomarkers", "value": [ { "id": "bmkr.criterion:66", "present": true, "subject": { "id": "bmkr:66", "type": "CategoricalVariant", "name": "FLT3-ITD", "constraints": [ { "type": "DefiningLocationConstraint", "location": { "id": "ga4gh:SL.53HN2VFdgurjdPcQYBRwyfNMHcwRzdID", "type": "SequenceLocation", "name": "FLT3 ITD Region (Exons 14-15), protein", "aliases": [], "description": "Sequence within refseq:NP_004110.2, the protein product of the MANE Select coding transcript for FLT3 (refseq:NM_004119.3), corresponding to the juxtamembrane domain and N-terminal portion of tyrosine kinase subdomain 1 (Exons 14-15).", "digest": "53HN2VFdgurjdPcQYBRwyfNMHcwRzdID", "sequenceReference": { "id": "ga4gh:SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH", "type": "SequenceReference", "name": "NP_004110.2", "aliases": [ "ensembl:ENSP00000241453.7", "ga4gh:SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH", "refseq:NP_004110.2" ], "description": "The protein product of the MANE Select coding transcript for FLT3 (refseq:NM_004119.3), corresponding to the Refseq protein accession NP_004110.2.", "moleculeType": "protein", "refgetAccession": "SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH", "residueAlphabet": "aa" }, "start": 568, "end": 648, "sequence": null }, "relations": [], "matchCharacteristic": { "primaryCoding": { "code": "is_within", "system": "ga4gh-gks-term:location-match" } } }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:3765", "conceptType": "Gene", "name": "FLT3", "primaryCoding": { "id": "coding:hgnc:3765", "code": "HGNC:3765", "system": "https://genenames.org", "iris": [ "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3765" ] }, "mappings": [ { "relation": "exactMatch", "coding": { "id": "coding:ensembl:ensg00000122025", "code": "ENSG00000122025", "system": "https://www.ensembl.org", "iris": [ "https://www.ensembl.org/id/ENSG00000122025" ] } }, { "relation": "exactMatch", "coding": { "id": "coding:ncbi:2322", "code": "2322", "system": "https://www.ncbi.nlm.nih.gov/gene", "iris": [ "https://www.ncbi.nlm.nih.gov/gene/2322" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:refseq:NM_004119.3", "code": "NM_004119.3", "system": "https://www.ncbi.nlm.nih.gov/nuccore", "iris": [ "https://www.ncbi.nlm.nih.gov/nuccore/NM_004119.3" ] } } ] } } ], "extensions": [ { "name": "biomarker_type", "value": "Somatic variant" }, { "name": "chromosome", "value": "13" }, { "name": "start_position", "value": null }, { "name": "end_position", "value": null }, { "name": "reference_allele", "value": null }, { "name": "alternate_allele", "value": null }, { "name": "cdna_change", "value": null }, { "name": "protein_change", "value": null }, { "name": "variant_annotation", "value": "Internal Tandem Duplication (ITD)" }, { "name": "exon", "value": null }, { "name": "rsid", "value": null }, { "name": "hgvsg", "value": null }, { "name": "hgvsc", "value": null }, { "name": "requires_oncogenic", "value": true } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }